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TREM2-IN-1
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Catalog No. T87562Cas No. 2000236-36-0
TREM2-IN-1 (OPA) is a platinum-based TREM2 inhibitor with anti-cancer activity, blocking DNA replication and inhibiting TREM2 on myeloid cells. It suppresses immune regulatory activity, reducing CD206 and CX3CR1 in a mouse model of colorectal cancer.
TREM2-IN-1
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Purity: 98.56%
Catalog No. T87562Cas No. 2000236-36-0
TREM2-IN-1 (OPA) is a platinum-based TREM2 inhibitor with anti-cancer activity, blocking DNA replication and inhibiting TREM2 on myeloid cells. It suppresses immune regulatory activity, reducing CD206 and CX3CR1 in a mouse model of colorectal cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $1,270 | In Stock | |
| 10 mg | Inquiry | 1-2 weeks | |
| 50 mg | Inquiry | 1-2 weeks |
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Purity:98.56%
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Product Introduction
Bioactivity
Chemical Properties
| Description | TREM2-IN-1 (OPA) is a platinum-based TREM2 inhibitor with anti-cancer activity, blocking DNA replication and inhibiting TREM2 on myeloid cells. It suppresses immune regulatory activity, reducing CD206 and CX3CR1 in a mouse model of colorectal cancer. |
| In vitro | TREM2-IN-1 (0.8 μM, 72 h) inhibited the early phase of DNA synthesis (G1 phase) in HCT-116 cells and had a strong pro-apoptotic ability. Trem2-in-1 (1 μM, 24 h) significantly inhibited the expression of TREM2 IN THP-1-derived macrophages. [1] |
| In vivo | TREM2-IN-1 (1.5 mg Pt per kg, treated, a single dose, lasting 15 days) was effective in inhibiting tumor growth in a C57BL/6 mouse model with MC38 mouse colon cancer and was less toxic overall. [1] |
| Molecular Weight | 1164.12 |
| Formula | C46H68N2O20Pt |
| Cas No. | 2000236-36-0 |
| Smiles | [O-](C(CCC(O[C@@H]1O[C@]2([C@]34[C@]([C@H]1C)(CC[C@@H](C)[C@@]3(CC[C@](C)(O2)OO4)[H])[H])[H])=O)=O)[Pt+4]56([O-]C(CCC(O[C@@H]7O[C@]8([C@]9%10[C@]([C@H]7C)(CC[C@@H](C)[C@@]9(CC[C@](C)(O8)OO%10)[H])[H])[H])=O)=O)([NH2]C%11C([NH2]5)CCCC%11)[O-]C(=O)C(=O)[O-]6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (68.72 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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