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TTP-8307
🥰Excellent
Catalog No. T13221Cas No. 950225-08-8
Alias TTP8307
TTP-8307 is an antiviral compound that inhibits the replication of rhinoviruses and enteroviruses, and inhibits coxsackievirus B3 and poliovirus by interfering with viral RNA synthesis.TTP-8307 can be used in the study of viral infections.
TTP-8307
🥰Excellent
Purity: 99.14%
Catalog No. T13221Alias TTP8307Cas No. 950225-08-8
TTP-8307 is an antiviral compound that inhibits the replication of rhinoviruses and enteroviruses, and inhibits coxsackievirus B3 and poliovirus by interfering with viral RNA synthesis.TTP-8307 can be used in the study of viral infections.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $954 | In Stock | |
| 50 mg | $1,240 | In Stock | |
| 100 mg | $1,990 | In Stock |
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CitedSelect Batch
Purity:99.14%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | TTP-8307 is an antiviral compound that inhibits the replication of rhinoviruses and enteroviruses, and inhibits coxsackievirus B3 and poliovirus by interfering with viral RNA synthesis.TTP-8307 can be used in the study of viral infections. |
| Targets&IC50 | Sabin poliovirus:0.85 μM (EC50), CVB3 Nancy:1.2 μM (EC50), Enteroviruses A16 and A21:5.34 μM (EC50) |
| In vitro | TTP-8307 targeted non-structural protein 3A and inhibited the replication of enterovirus B3 (CVB3 Nancy) with an EC50 of 1.2 μM. In addition, TTP-8307 inhibited the replication of three Sabin poliovirus strains, as well as enteroviruses A16 and A21, with EC50s of 0.85 and 5.34 μM, respectively.Meanwhile, TTP-8307 inhibited the replication of human rhinoviruses (HRVs) 2, 29, 39, 45, 63 and 85 was also inhibitory. Mutations in non-structural protein 3A caused resistance to TTP-8307, a novel enterovirus replication inhibitor. In addition, TTP-8307 inhibits OSBP-dependent viruses, including encephalomyelitis virus (EMCV) and hepatitis C virus (HCV). [1][2] |
| Alias | TTP8307 |
| Molecular Weight | 436.48 |
| Formula | C27H21FN4O |
| Cas No. | 950225-08-8 |
| Smiles | C(N[C@H](C)C1=CC=C(F)C=C1)(=O)C=2C=C(C=3NC(=NC3)C4=CC5=C(C=N4)C=CC=C5)C=CC2 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (183.28 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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