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UNC926 hydrochloride

Name: UNC926 hydrochloride
Brand: TargetMol
SKU: T9221
Price: 80 USD
Availability: InStock
Rating: 5 (10 reviews)

UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor.

Catalog No. T9221Cas No. 1782573-49-2

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Purity:98.71%

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COA HPLC HNMR

UNC926 hydrochloride

Catalog No. T9221Cas No. 1782573-49-2

UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$80	In Stock
5 mg	$181	In Stock
10 mg	$272	In Stock
25 mg	$448	In Stock
50 mg	$630	In Stock
100 mg	$852	In Stock
200 mg	$1,130	In Stock
1 mL x 10 mM (in DMSO)	$187	In Stock

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Product Introduction

Bioactivity

Description	UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor.
Targets&IC50	L3MBTL1:3.9 μM, L3MBTL3:3.2 μM, L3MBTL4:15.6 μM
In vitro	UNC926 demonstrates a low micromolar affinity toward L3MBTL3, exhibiting an IC50 of 3.2 μM, and shows diminished affinity for other MBT domains without binding to CBX7. In a concentration-dependent manner ranging from 1-25 μM, UNC926 effectively inhibits the interaction between the 3xMBT domain and H4K20me1 and impedes the association of L3MBTL1's 3xMBT with specific histone peptides. However, it does not disrupt the binding of 53BP1 to H4K20me1, indicating that UNC926 specifically targets L3MBTL1 rather than 53BP1.

Chemical Properties

Molecular Weight	373.72
Formula	C₁₆H₂₂BrClN₂O
Cas No.	1782573-49-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 150 mg/mL (444.77 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6758 mL	13.3790 mL	26.7580 mL	133.7900 mL
5 mM	0.5352 mL	2.6758 mL	5.3516 mL	26.7580 mL
10 mM	0.2676 mL	1.3379 mL	2.6758 mL	13.3790 mL
20 mM	0.1338 mL	0.6690 mL	1.3379 mL	6.6895 mL
50 mM	0.0535 mL	0.2676 mL	0.5352 mL	2.6758 mL
100 mM	0.0268 mL	0.1338 mL	0.2676 mL	1.3379 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc