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VU0360172

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Purity:99.65%

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COA HNMR HPLC

VU0360172

Catalog No. T29126Cas No. 1310012-12-4

VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).

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Pack Size	Price	Availability
1 mg	$74	In Stock
5 mg	$178	In Stock
10 mg	$289	In Stock
25 mg	$592	In Stock
50 mg	$853	In Stock
100 mg	$1,180	In Stock
1 mL x 10 mM (in DMSO)	$167	In Stock

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Product Introduction

Bioactivity

Description	VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).
In vivo	VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[4].
Alias	VU-0360172, VU 0360172

Chemical Properties

Molecular Weight	294.32
Formula	C18H15FN2O
Cas No.	1310012-12-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83 mg/mL (282.01 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3977 mL	16.9883 mL	33.9766 mL	169.8831 mL
5 mM	0.6795 mL	3.3977 mL	6.7953 mL	33.9766 mL
10 mM	0.3398 mL	1.6988 mL	3.3977 mL	16.9883 mL
20 mM	0.1699 mL	0.8494 mL	1.6988 mL	8.4942 mL
50 mM	0.0680 mL	0.3398 mL	0.6795 mL	3.3977 mL
100 mM	0.0340 mL	0.1699 mL	0.3398 mL	1.6988 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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