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WIN 54954

WIN 54954
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Purity:98.58%
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WIN 54954

Catalog No. T61652Cas No. 107355-45-3
WIN 54954 is an orally available antiviral agent that inhibits Coxsackievirus and inhibits viral translation or transcription.WIN 54954 may be useful in the study of small ribonucleic acid virus infections.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$52In Stock
2 mg$74In Stock
5 mg$123In Stock
10 mg$198In Stock
25 mg$372In Stock
50 mg$619In Stock
100 mg$1,090In Stock
500 mg$2,230In Stock
1 mL x 10 mM (in DMSO)$135In Stock
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Product Introduction

Bioactivity
Description
WIN 54954 is an orally available antiviral agent that inhibits Coxsackievirus and inhibits viral translation or transcription.WIN 54954 may be useful in the study of small ribonucleic acid virus infections.
In vitro
WIN 54954 reduced plaque formation by 50 of 52 serotypes of rhinovirus (MIC range: 0.007 to 2.2 μg/ml). A concentration of 0.28 μg/ml effectively inhibited 80% of the 52 serotypes (EC80). WIN 54954 also effectively inhibited 15 commonly isolated enteroviruses, with an EC80 of 0.06 μg/ml[1].
In vivo
A single gastric dose of WIN 54954 at daily doses of 2 and 100 mg/kg protected 50% of mice from paralysis after infection with Coxsackie virus A-9 and ECHO virus-9, respectively (PD50)[1].
Chemical Properties
Molecular Weight383.27
FormulaC18H20Cl2N2O3
Cas No.107355-45-3
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (208.73 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6091 mL13.0456 mL26.0913 mL130.4563 mL
5 mM0.5218 mL2.6091 mL5.2183 mL26.0913 mL
10 mM0.2609 mL1.3046 mL2.6091 mL13.0456 mL
20 mM0.1305 mL0.6523 mL1.3046 mL6.5228 mL
50 mM0.0522 mL0.2609 mL0.5218 mL2.6091 mL
100 mM0.0261 mL0.1305 mL0.2609 mL1.3046 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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