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Zenocutuzumab
🥰Excellent
Catalog No. T76948Cas No. 1969309-56-5
Alias R040517, R 040517, PB4188, PB 4188, MCLA-128, MCLA128
Zenocutuzumab (MCLA-128) is a humanized antibody targeting the extracellular domains of HER2 and HER3. It can be used for research on tumors driven by NRG1 gene rearrangement.
Zenocutuzumab
Zenocutuzumab
🥰Excellent
Purity: 97%
Catalog No. T76948Alias R040517, R 040517, PB4188, PB 4188, MCLA-128, MCLA128Cas No. 1969309-56-5
Zenocutuzumab (MCLA-128) is a humanized antibody targeting the extracellular domains of HER2 and HER3. It can be used for research on tumors driven by NRG1 gene rearrangement.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $1,025 | In Stock | |
| 5 mg | $2,465 | In Stock | |
| 10 mg | $3,685 | In Stock |
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Concentration:10.013 mg/mL
Purity:97%
Contact us for more batch information
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Product Introduction
Bioactivity
Chemical Properties
| Description | Zenocutuzumab (MCLA-128) is a humanized antibody targeting the extracellular domains of HER2 and HER3. It can be used for research on tumors driven by NRG1 gene rearrangement. |
| In vitro | Zenocutuzumab (MCLA-128) (0.001-1000 nM, treated for 96 hours) inhibits the growth of lung and breast cancer cell lines. [1] Zenocutuzumab (0.1-1000 nM, treated for 24 hours) induces apoptosis and triggers expression of markers of cell cycle arrest in lung and breast cancer cell lines by inhibiting phosphorylation of HER3 and AKT. [1] |
| In vivo | Zenocutuzumab (2.5-25 mg/kg, intraperitoneal injection once weekly for 28 days) significantly reduced tumor growth and triggered tumor shrinkage and even regression. [1] |
| Alias | R040517, R 040517, PB4188, PB 4188, MCLA-128, MCLA128 |
| Cas No. | 1969309-56-5 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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