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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $41 | 6-8 weeks | |
5 mg | $97 | 6-8 weeks | |
10 mg | $172 | 6-8 weeks | |
25 mg | $378 | 6-8 weeks | |
50 mg | $647 | 6-8 weeks | |
100 mg | $997 | 6-8 weeks | |
500 mg | $1,990 | 6-8 weeks | |
1 mL x 10 mM (in DMSO) | $107 | 6-8 weeks |
Description | (5Z,2E)-CU-3 is a potent and selective inhibitor of DGKα isozyme with an IC50 value of 0.6 μM and inhibition of DGKα by competing ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 is selective, targeting the catalytic region of DGKα, but does not act on the regulatory region. (5Z,2E)-CU-3 has antitumor and immunogenic effects, promoting apoptosis of cancer cells and activation of T cells. |
In vitro | (5Z,2E)-CU-3 induced apoptosis in HepG2 hepatocellular carcinoma and HeLa cervical cancer cells while simultaneously enhancing the interleukin-2 production of Jurkat T cells[1]. |
Molecular Weight | 392.47 |
Formula | C16H12N2O4S3 |
Cas No. | 1815598-71-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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