Shopping Cart
- Remove All
Your shopping cart is currently empty
(Rac)-Modipafant
Catalog No. T28081Cas No. 122956-68-7
Alias UK-74505, UK74505, UK 74505, Modipafant racemate
(Rac)-Modipafantis an orally available and selective platelet-activating factor receptor (PAFR) antagonist that inhibits PAF-induced aggregation of washed platelets in rabbits, and can be used to study arthritis and ischemia/reperfusion (I/R) in the superior mesenteric artery (SMA) of the rat.
(Rac)-Modipafant
Catalog No. T28081Alias UK-74505, UK74505, UK 74505, Modipafant racemateCas No. 122956-68-7
(Rac)-Modipafantis an orally available and selective platelet-activating factor receptor (PAFR) antagonist that inhibits PAF-induced aggregation of washed platelets in rabbits, and can be used to study arthritis and ischemia/reperfusion (I/R) in the superior mesenteric artery (SMA) of the rat.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $219 | In Stock | |
| 5 mg | $548 | In Stock | |
| 10 mg | $792 | In Stock | |
| 25 mg | $1,220 | In Stock | |
| 50 mg | $2,380 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "(Rac)-Modipafant"
Ginkgolide B
Cited
BN-52021
T275115291-77-7
Ginkgolide B (BN-52021) is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba.
- $57
Size
QTY
Cited48740 RP
RP-55778, RP-48740, RP 55779, RP 55778
T1015993363-11-2In house
48740 RP (RP 55779) is an antagonist of platelet-activating factor.
- $375
Size
QTY
Rupatadine Fumarate
Rupafin, Rinialer, Alergoliber
T6242182349-12-8
Rupatadine Fumarate (Rinialer) (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.
- $32
Size
QTY
CV-6209
CV6209, CV 6209
T27102100488-87-7In house
CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor.
- $129
Size
QTY
Zingiberen newsaponin
Zingiberensis saponin I
TN232991653-50-8
Zingiberen newsaponin is a steroidal saponin from Dioscorea zingiberensis.
- $98
Size
QTY
Ferulamide
4-Hydroxy-3-methoxycinnamide
TN164361012-31-5
Ferulamide (4-Hydroxy-3-methoxycinnamide), a Ferulic acid derivative, shows potent inhibitory activity against arachidonic acid-induced platelet aggregation.
- $185
Size
QTY
Apafant
WEB-2086, WEB2086, WEB 2086
T14300105219-56-5
Apafant (WEB 2086) is a highly potent platelet activating factor (PAF) antagonist that blocks eosinophil activation and can be used to study experimental allergic conjunctivitis in guinea pigs.
- $113
Size
QTY
Scutellarein tetramethyl ether Cited
4',5,6,7-Tetramethoxyflavone
TN12711168-42-9
Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is extracted from Siam weeds and demonstrates anti-inflammatory activity via the NF-κB pathway.
- $83
Size
QTY
Cited(-)-Denudatin B
Denudatin B
TN383187402-88-8
(-)-Denudatin B (Denudatin B) is derived from Magnolia fargesii. (-)-Denudatin B has nonspecific antiplatelet action at high concentration by inhibiting phosphoinositides breakdown induced by collagen and thrombin.
- $85
Size
QTY
Yangambin
TN232213060-14-5
Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibition the Ca2+ influx through voltage-gated Ca2+ channels. Yangambin also has central nervous system activity.
- $126
Size
QTY
Niranthin
TN466050656-77-4
Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interacting with both subunits of the enzyme. Niranthin also exhibits anti-hepatitis B virus, antiinflammatory and antiallodynic actions.
- $198
Size
QTY
Select Batch
Purity:98.09%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | (Rac)-Modipafantis an orally available and selective platelet-activating factor receptor (PAFR) antagonist that inhibits PAF-induced aggregation of washed platelets in rabbits, and can be used to study arthritis and ischemia/reperfusion (I/R) in the superior mesenteric artery (SMA) of the rat. |
| In vivo | In anesthetized guinea pigs, (Rac)-Modipafant(UK-74505) at 30 and 100 μg/kg intravenously inhibited the bronchoconstrictor response to aerosolized PAF without affecting blood pressure or heart rate; oral (Rac)-Modipafant(UK-74505) inhibited the increase in permeability of rat skin vessels to intradermal PAF with an ED50 of 280 +/- 5 μg/kg; and in conscious dogs, complete inhibition of PAF-induced whole blood aggregation occurred in vitro for at least 14 hours following an oral dose of (Rac)-Modipafant(UK-74505)(75 μg/kg).[2] |
| Alias | UK-74505, UK74505, UK 74505, Modipafant racemate |
| Molecular Weight | 605.09 |
| Formula | C34H29ClN6O3 |
| Cas No. | 122956-68-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (66.11 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy (Rac)-Modipafant | purchase (Rac)-Modipafant | (Rac)-Modipafant cost | order (Rac)-Modipafant | (Rac)-Modipafant chemical structure | (Rac)-Modipafant in vivo | (Rac)-Modipafant formula | (Rac)-Modipafant molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.