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(S)-Terazosin
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Catalog No. T12815Cas No. 109351-33-9
(S)-Terazosin is an active S-enantiomer of Terazosin and acts as a potent, high-affinity antagonist of α-adrenoceptors [α1a, α1b, and α1d-adrenoceptors] with Ki values of 3.91 nM, 0.79 nM, and 1.16 nM, respectively.
(S)-Terazosin
😃Good
Catalog No. T12815Cas No. 109351-33-9
(S)-Terazosin is an active S-enantiomer of Terazosin and acts as a potent, high-affinity antagonist of α-adrenoceptors [α1a, α1b, and α1d-adrenoceptors] with Ki values of 3.91 nM, 0.79 nM, and 1.16 nM, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $119 | 5 days | |
| 5 mg | $198 | 5 days | |
| 50 mg | $789 | 6-8 weeks | |
| 100 mg | $1,240 | 6-8 weeks | |
| 1 mL x 10 mM (in DMSO) | $226 | 5 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | (S)-Terazosin is an active S-enantiomer of Terazosin and acts as a potent, high-affinity antagonist of α-adrenoceptors [α1a, α1b, and α1d-adrenoceptors] with Ki values of 3.91 nM, 0.79 nM, and 1.16 nM, respectively. |
| Targets&IC50 | α2C-adrenoceptor:46.4 nM (ki), α1B-adrenoceptor:0.79 nM (ki), α1A-adrenoceptor:ki： 3.91 nM , α2A-adrenoceptor: 729 nM (ki), α2B-adrenoceptor:3.5 nM (ki), α1D-adrenoceptor:1.16 nM (ki) |
| In vitro | (S)-Terazosin and its enantiomers show high and apparently equal affinity for subtypes of α1-adrenoceptors, and showed potent α1-adrenoceptors antagonist in isolated tissues, with the enantiomers approximately equipotent to the racemate at each α1-adrenoceptor subtype. At α2b sites, (R)-Terazosin binds less potently than either the (S)-Terazosin or racemate. |
| In vivo | (S)-Terazosin shows α2B receptor antagonist at rat atrial(pEC30 of 6.93). (s)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA2 values of 8.3 and 6.12, respectively. |
| Molecular Weight | 387.43 |
| Formula | C19H25N5O4 |
| Cas No. | 109351-33-9 |
| Relative Density. | 1.332 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 150 mg/mL (387.17 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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