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α-Cyano-4-hydroxycinnamic acid

Catalog No. T7460   CAS 28166-41-8
Synonyms: α-Cyano-4-hydroxycinnamic acid(α-CHCA)

α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamic acid(α-CHCA)) (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 : 1.5 μM).

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α-Cyano-4-hydroxycinnamic acid Chemical Structure
α-Cyano-4-hydroxycinnamic acid, CAS 28166-41-8
Pack Size Availability Price/USD Quantity
50 mg In stock $ 45.00
100 mg In stock $ 64.00
200 mg In stock $ 94.00
1 mL * 10 mM (in DMSO) In stock $ 39.00
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Purity: 99.8%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamic acid(α-CHCA)) (α-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 : 1.5 μM).
In vitro The effectiveness of CHC in glioma cells appears to be dependent on Monocarboxylate transporters (MCTs) membrane expression.?MCT1 downregulation showed similar effects on different glioma cells, supporting CHC as an MCT1 inhibitor.?There was a synergistic effect when combining CHC with temozolomide treatment in U251 cells.?In the CAM in vivo model, CHC decreased the size of tumors and the number of blood vessels formed[1].
Cell Research Cells were plated into 96-well plates, at a density of 3 × 10^3 cells per well.?The effect of treatment with CHC (0.6–12 mM) on cell number (total biomass) was determined at 24, 48, and 72 h by the?sulforhodamine B assay (SRB, TOX-6).?IC50 values (CHC concentration that corresponds to 50% of cell growth inhibition) were estimated from 3 independent experiments, each one in triplicate, using GraphPad Software.?Cell proliferation assay was performed as previously described32 and assessed under the treatment conditions previously described, for 5 mM and 10 mM of CHC.?After CHC treatment, cells were incubated with BrdU and its incorporation was assessed at 450 nm (λref = 655 nm) .?Cell growth (total biomass) and cell proliferation for glioma siMCT1 cells and the effect of CHC (1.25–15 mM) on cell number were performed[1].
Synonyms α-Cyano-4-hydroxycinnamic acid(α-CHCA)
Molecular Weight 189.17
Formula C10H7NO3
CAS No. 28166-41-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 37mg/mL(195.59mM)

TargetMolReferences and Literature

1. Miranda-Goncalves V , Honavar M , Pinheiro C , et al. Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets[J]. Neuro-Oncology, 2013, 15(2):172-188. 2. Colen C B , Shen Y , Ghoddoussi F , et al. Metabolic Targeting of Lactate Efflux by Malignant Glioma Inhibits Invasiveness and Induces Necrosis: An In Vivo Study[J]. Neoplasia, 2011, 13(7):620-632.

TargetMolCitations

1. Tong Y, Guo C, Liu Z, et al. In situ localization of tris-(2, 3-dibromopropyl) isocyanurate in mouse organs by MALDI-IMS with auxiliary matrix strategy. Talanta. 2021: 122723.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Bioactive Compound Library Cuproptosis Compound Library Mitochondria-Targeted Compound Library Inhibitor Library Ion Channel Inhibitor Library Target-Focused Phenotypic Screening Library Covalent Inhibitor Library Anti-Cancer Compound Library NO PAINS Compound Library

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Keywords

α-Cyano-4-hydroxycinnamic acid 28166-41-8 Membrane transporter/Ion channel Monocarboxylate transporter matrix-assisted MALDI-TOF matrix Inhibitor lactate a-Cyano-4-hydroxycinnamic acid applications MCTs pyruvate laser desorption α-Cyano-4-hydroxycinnamic acid(α-CHCA) spectrometry ionization Monocarboxylate Transporter a-Cyano-4-hydroxycinnamic acid(a-CHCA) transporter α Cyano 4 hydroxycinnamic acid peptide inhibit alpha-Cyano-4-hydroxycinnamic acid alpha-Cyano-4-hydroxycinnamic acid(alpha-CHCA) αCyano4hydroxycinnamic acid facilitate inhibitor

 

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