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β-NETA

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Catalog No. T14194Cas No. 31059-54-8

β-NETA (α-NETA) is a stable, noncompetitive, slowly reversible choline acetyltransferase (ChAT) inhibitor with an IC50 of 9 μM and is a potent chemokine-like receptor-1 (CMKLR1) antagonist. β-NETA has anti-cancer activity[1][2]. β-NETA weakly inhibits cholinesterase (IC50=84 µM) and acetylcholinesterase (IC50=300 µM).

β-NETA

β-NETA

🥰Excellent
Purity: 98%
Catalog No. T14194Cas No. 31059-54-8
β-NETA (α-NETA) is a stable, noncompetitive, slowly reversible choline acetyltransferase (ChAT) inhibitor with an IC50 of 9 μM and is a potent chemokine-like receptor-1 (CMKLR1) antagonist. β-NETA has anti-cancer activity[1][2]. β-NETA weakly inhibits cholinesterase (IC50=84 µM) and acetylcholinesterase (IC50=300 µM).
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2 mg$30In Stock
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1 mL x 10 mM (in DMSO)$68In Stock
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Purity:98%
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Product Introduction

Bioactivity
Description
β-NETA (α-NETA) is a stable, noncompetitive, slowly reversible choline acetyltransferase (ChAT) inhibitor with an IC50 of 9 μM and is a potent chemokine-like receptor-1 (CMKLR1) antagonist. β-NETA has anti-cancer activity[1][2]. β-NETA weakly inhibits cholinesterase (IC50=84 µM) and acetylcholinesterase (IC50=300 µM).
Targets&IC50
AChE:300 μM, ChE:84 μM, ChAT:9 μM
In vitro
a-NETA treatment increases EOC cell expression of pyroptosis-associated proteins[3]. a-NETA (50-150 nM; 24 hours) decreases all cell lines viability in a dose-dependent manner [3]. a-NETA (2.5-10.0 μg/mL; 24 hours) leads to epithelial ovarian cancer (EOC) cell death associated with membrane blistering and cytoplasm leakage[3].
In vivo
a-NETA (s.c. injection; 3 mg/kg or 10 mg/kg; daily; for 30 days) significantly delays the onset of EAE with 3 mg/kg, and completely suppresses clinical signs for an average of nine days with 10 mg/kg beyond the first appearance of disease in control female C57BL/6 mice[2]. a-NETA (injected intraperitoneally; 0.125 mg/kg; once every other day for 20 days) significantly decreases tumor volume and tumor weight[3].
Chemical Properties
Molecular Weight369.24
FormulaC16H20INO
Cas No.31059-54-8
Smiles[I-].C[N+](C)(C)CCC(=O)c1ccc2ccccc2c1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 31.25 mg/mL (84.63 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7083 mL13.5413 mL27.0827 mL135.4133 mL
5 mM0.5417 mL2.7083 mL5.4165 mL27.0827 mL
10 mM0.2708 mL1.3541 mL2.7083 mL13.5413 mL
20 mM0.1354 mL0.6771 mL1.3541 mL6.7707 mL
50 mM0.0542 mL0.2708 mL0.5417 mL2.7083 mL

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