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1-Deoxymannojirimycin hydrochloride

Catalog No. T22468Cas No. 73465-43-7

1-Deoxymannojirimycin hydrochloride, a selective α1,2-mannosidase inhibitor (IC50: 20 μM), also inhibits HIV-1 strains but exhibits poor antiviral activity.

1-Deoxymannojirimycin hydrochloride

1-Deoxymannojirimycin hydrochloride

Catalog No. T22468Cas No. 73465-43-7
1-Deoxymannojirimycin hydrochloride, a selective α1,2-mannosidase inhibitor (IC50: 20 μM), also inhibits HIV-1 strains but exhibits poor antiviral activity.
Pack SizePriceAvailabilityQuantity
1 mg$6835 days
5 mg$21035 days
10 mg$31535 days
25 mg$52535 days
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Product Introduction

Bioactivity
Description
1-Deoxymannojirimycin hydrochloride, a selective α1,2-mannosidase inhibitor (IC50: 20 μM), also inhibits HIV-1 strains but exhibits poor antiviral activity.
Targets&IC50
α1/2 mannosidase I:20 μM
In vitro
Exposure of such mutant virus strains to 1-Deoxymannojirimycin results in an enhanced suppression of mutant virus-induced cytopathicity in CEM cell cultures[1].When combined with CBAs at concentrations that showed poor if any suppression of mutant virus replication as single drugs, a synergistic antiviral activity of 1-Deoxymannojirimycin was observed[1].
Chemical Properties
Molecular Weight199.63
FormulaC6H14ClNO4
Cas No.73465-43-7
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 20 mg/mL (100.19 mM)
H2O: 20 mg/mL (100.19 mM)
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM5.0093 mL25.0463 mL50.0927 mL250.4634 mL
5 mM1.0019 mL5.0093 mL10.0185 mL50.0927 mL
10 mM0.5009 mL2.5046 mL5.0093 mL25.0463 mL
20 mM0.2505 mL1.2523 mL2.5046 mL12.5232 mL
50 mM0.1002 mL0.5009 mL1.0019 mL5.0093 mL
100 mM0.0501 mL0.2505 mL0.5009 mL2.5046 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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