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11β-HSD1 inibitor 19

11β-HSD1 inibitor 19 shows inhibitory activities for hHSD1 and mHSD1 with IC50s of 16 nM and 10 nM.

Catalog No. T72022Cas No. 946400-19-7

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Purity:99.46%

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COA HNMR LCMS HPLC

11β-HSD1 inibitor 19

Catalog No. T72022Cas No. 946400-19-7

11β-HSD1 inibitor 19 shows inhibitory activities for hHSD1 and mHSD1 with IC50s of 16 nM and 10 nM.

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Pack Size	Price	Availability
1 mg	$350	In Stock
5 mg	$828	In Stock
10 mg	$1,130	In Stock
25 mg	$1,590	In Stock
50 mg	$1,980	In Stock
100 mg	$2,500	In Stock
500 mg	$4,900	In Stock

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Product Introduction

Bioactivity

Description	11β-HSD1 inibitor 19 shows inhibitory activities for hHSD1 and mHSD1 with IC50s of 16 nM and 10 nM.
Targets&IC50	HSD1 (human):16 nM, HSD1 (mouse):10 nM

Chemical Properties

Molecular Weight	461.86
Formula	C₁₉H₁₆ClF₄N₃O₂S
Cas No.	946400-19-7

Storage & Solubility Information

Storage

Shipping with blue ice.

Solubility Information

DMSO: 55 mg/mL (119.08 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1652 mL	10.8258 mL	21.6516 mL	108.2579 mL
5 mM	0.4330 mL	2.1652 mL	4.3303 mL	21.6516 mL
10 mM	0.2165 mL	1.0826 mL	2.1652 mL	10.8258 mL
20 mM	0.1083 mL	0.5413 mL	1.0826 mL	5.4129 mL
50 mM	0.0433 mL	0.2165 mL	0.4330 mL	2.1652 mL
100 mM	0.0217 mL	0.1083 mL	0.2165 mL	1.0826 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

11beta-HSD1 inibitor 1911b-HSD1 inibitor 1911β-HSD1 inibitor 193chloro4[[(2R)4[4fluoro2(trifluoromethyl)phenyl]2methyl1piperazinyl]sulfonyl]Benzonitrile