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CYM50358

CYM50358
N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4 with an IC50 of 25 nM.
Catalog No. T9464Cas No. 1314212-39-9
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Purity:99.76%
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CYM50358

Catalog No. T9464Cas No. 1314212-39-9

N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4 with an IC50 of 25 nM.
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Pack SizePriceAvailabilityQuantity
1 mg$51In Stock
5 mg$122In Stock
10 mg$198In Stock
25 mg$455In Stock
50 mg$672In Stock
100 mg$956In Stock
1 mL x 10 mM (in DMSO)$133In Stock
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Product Introduction

Bioactivity
Description
N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4 with an IC50 of 25 nM.
Targets&IC50
S1PR4:25 nM
In vitro
N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 shows less potent inhibition of S1PR1(IC50=6.4μM)[1].N-(4-(aminomethyl)-2,6-dimethylphenyl)-5(10μM)has no effect on the collagen-induced HSP27 phosphorylation,markedly reverses the suppressive effect of S1P on the collagen-induced phospphorylation of HSP27[2].
Chemical Properties
Molecular Weight389.28
FormulaC20H18Cl2N2O2
Cas No.1314212-39-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 125 mg/mL (321.11 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5688 mL12.8442 mL25.6885 mL128.4423 mL
5 mM0.5138 mL2.5688 mL5.1377 mL25.6885 mL
10 mM0.2569 mL1.2844 mL2.5688 mL12.8442 mL
20 mM0.1284 mL0.6422 mL1.2844 mL6.4221 mL
50 mM0.0514 mL0.2569 mL0.5138 mL2.5688 mL
100 mM0.0257 mL0.1284 mL0.2569 mL1.2844 mL

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