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17α-Hydroxyprogesterone

Catalog No. T1429Cas No. 68-96-2
Alias Hydroxyprogesterone, 17-OHP, 17-Hydroxyprogesterone

17α-Hydroxyprogesterone (17-OHP) is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor-mediated gene expression.

17α-Hydroxyprogesterone

17α-Hydroxyprogesterone

Purity: 99.79%
Catalog No. T1429Alias Hydroxyprogesterone, 17-OHP, 17-HydroxyprogesteroneCas No. 68-96-2
17α-Hydroxyprogesterone (17-OHP) is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor-mediated gene expression.
Pack SizePriceAvailabilityQuantity
1 g$25In Stock
1 mL x 10 mM (in DMSO)$28In Stock
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Purity:99.79%
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Product Introduction

Bioactivity
Description
17α-Hydroxyprogesterone (17-OHP) is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor-mediated gene expression.
In vitro
17α-Hydroxyprogesterone is an agonist of the progesterone receptor (PR) similarly to progesterone, albeit weakly in comparison[1]. It is a chemical intermediate in the biosynthesis of steroid hormones, including the androgen and estrogen sex hormones and the glucocorticoids and mineralocorticoids.
In vivo
17-Hydroxyprogesterone is a potent steroid inducer of GVBD (germinal vesicle breakdown)[3].
AliasHydroxyprogesterone, 17-OHP, 17-Hydroxyprogesterone
Chemical Properties
Molecular Weight330.46
FormulaC21H30O3
Cas No.68-96-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (151.3 mM), Sonication is recommended.
Ethanol: 61 mg/mL (184.6 mM)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM3.0261 mL15.1304 mL30.2608 mL151.3042 mL
5 mM0.6052 mL3.0261 mL6.0522 mL30.2608 mL
10 mM0.3026 mL1.5130 mL3.0261 mL15.1304 mL
20 mM0.1513 mL0.7565 mL1.5130 mL7.5652 mL
50 mM0.0605 mL0.3026 mL0.6052 mL3.0261 mL
100 mM0.0303 mL0.1513 mL0.3026 mL1.5130 mL

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