Powder: -20°C for 3 years | In solvent: -80°C for 1 year
3-Deazauridine (NSC-126849) is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary mode of action of this nucleoside analog.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 39.00 | |
25 mg | In stock | $ 80.00 | |
50 mg | In stock | $ 128.00 | |
100 mg | In stock | $ 197.00 | |
500 mg | In stock | $ 516.00 |
Description | 3-Deazauridine (NSC-126849) is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary mode of action of this nucleoside analog. |
In vitro | 3-Deazauridine enhanced the in vitro antineoplastic action of 5-AZA-CdR on human leukemic cells by increasing its incorporation into DNA. Using an optimized dose-schedule we showed that this combination could cure some mice bearing L1210 leukemia, even in the presence of a subpopulation of drug-resistant (L1210/ARA-C) leukemic cells lacking DCK. 3-Deazauridine alone also cured some mice with L1210/ARA-C leukemia[1]. |
Synonyms | NSC 126849 |
Molecular Weight | 243.21 |
Formula | C10H13NO6 |
CAS No. | 23205-42-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (185.03 mM)
DMF: 16 mg/mL
You can also refer to dose conversion for different animals. More
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3-Deazauridine 23205-42-7 Cell Cycle/Checkpoint DNA Damage/DNA Repair Nucleoside Antimetabolite/Analog NSC126849 NSC-126849 3Deazauridine NSC 126849 3 Deazauridine inhibitor inhibit