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3-Deazauridine (NSC-126849) is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary mode of action of this nucleoside analog.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | 45 € | In Stock | |
50 mg | 73 € | In Stock | |
100 mg | 112 € | In Stock | |
200 mg | 169 € | In Stock |
Description | 3-Deazauridine (NSC-126849) is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary mode of action of this nucleoside analog. |
In vitro | 3-Deazauridine enhanced the in vitro antineoplastic action of 5-AZA-CdR on human leukemic cells by increasing its incorporation into DNA. Using an optimized dose-schedule we showed that this combination could cure some mice bearing L1210 leukemia, even in the presence of a subpopulation of drug-resistant (L1210/ARA-C) leukemic cells lacking DCK. 3-Deazauridine alone also cured some mice with L1210/ARA-C leukemia[1]. |
Alias | NSC 126849 |
Molecular Weight | 243.21 |
Formula | C10H13NO6 |
Cas No. | 23205-42-7 |
Smiles | O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)C=C(O)C=C2 |
Relative Density. | 1.718 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (185.03 mM) DMF: 16 mg/mL | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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