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3-Deazauridine

Catalog No. T36866   CAS 23205-42-7
Synonyms: NSC 126849

3-Deazauridine (NSC-126849) is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary mode of action of this nucleoside analog.

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3-Deazauridine Chemical Structure
3-Deazauridine, CAS 23205-42-7
Pack Size Availability Price/USD Quantity
10 mg In stock $ 39.00
25 mg In stock $ 80.00
50 mg In stock $ 128.00
100 mg In stock $ 197.00
500 mg In stock $ 516.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 3-Deazauridine (NSC-126849) is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary mode of action of this nucleoside analog.
In vitro 3-Deazauridine enhanced the in vitro antineoplastic action of 5-AZA-CdR on human leukemic cells by increasing its incorporation into DNA. Using an optimized dose-schedule we showed that this combination could cure some mice bearing L1210 leukemia, even in the presence of a subpopulation of drug-resistant (L1210/ARA-C) leukemic cells lacking DCK. 3-Deazauridine alone also cured some mice with L1210/ARA-C leukemia[1].
Synonyms NSC 126849
Molecular Weight 243.21
Formula C10H13NO6
CAS No. 23205-42-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (185.03 mM)

DMF: 16 mg/mL

TargetMolReferences and Literature

1. Raynal NJ, et al. 3-Deazauridine enhances the antileukemic action of 5-aza-2'-deoxycytidine and targets drug-resistance due to deficiency in deoxycytidine kinase. Leuk Res. 2011 Jan;35(1):110-8. 2. Moriconi WJ, Slavik M, Taylor S. 3-Deazauridine (NSC 126849): an interesting modulator of biochemical response. Invest New Drugs. 1986;4(1):67-84. 3. Grant S, Cadman E. Altered 5-azacytidine metabolism following 3-deazauridine treatment of L5178Y and human myeloblasts. Cancer Res. 1980 Nov;40(11):4000-6.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max DNA Damage & Repair Compound Library Inhibitor Library Bioactive Compound Library Nucleotide Compound Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets
L-Uridine Dacarbazine Ascamycin Fludarabine Phosphate S-Gem Deoxycytidine triphosphate Orotic acid zinc Homouridine

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Keywords

3-Deazauridine 23205-42-7 Cell Cycle/Checkpoint DNA Damage/DNA Repair Nucleoside Antimetabolite/Analog NSC126849 NSC-126849 3Deazauridine NSC 126849 3 Deazauridine inhibitor inhibit

 

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