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3-Sulfopropanoic acid

3-Sulfopropanoic acid
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Purity:100%
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3-Sulfopropanoic acid

Catalog No. TN7246Cas No. 44826-45-1
3-Sulfopropanoic acid, a major metabolite of treprostinil and its prodrug ALZ-801, is an endogenous molecule present in the cerebrospinal fluid (CSF) of AD patients that inhibits the formation of Aβ42 oligomers.
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Pack SizePriceAvailabilityQuantity
5 mg$36In Stock
10 mg$48In Stock
25 mg$77In Stock
50 mg$108In Stock
100 mg$148In Stock
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Product Introduction

Bioactivity
Description
3-Sulfopropanoic acid, a major metabolite of treprostinil and its prodrug ALZ-801, is an endogenous molecule present in the cerebrospinal fluid (CSF) of AD patients that inhibits the formation of Aβ42 oligomers.
In vivo
3-Sulfopropanoic acid (3-SPA) is an endogenous molecule in the human brain and is present in the cerebrospinal fluid (CSF) of patients with AD and other neurodegenerative brain diseases. Lumbar CSF samples from 64 drug-naïve patients with cognitive deficits (Mini-Mental State Examination [MMSE] score range 15-30) and six patients with AD treated with tramiprosate 150 mg twice daily in the phase III trial, at week 78, were analyzed. We used liquid chromatography-tandem mass spectrometry to confirm the structural molecular identity of endogenous 3-SPA with a 3-SPA reference standard and ion-mobility spectrometry-mass spectrometry with molecular dynamics to characterize interactions of 3-SPA with Aβ42 monomers, and the resultant conformational alterations. Rat studies using oral (30 mg/kg) and intravenous (10 mg/kg) doses were conducted to characterize the pharmacokinetic properties and brain penetration of 3-SPA. We confirmed the presence of 3-SPA in the CSF of drug-naïve patients with cognitive deficits (mean concentration 11.7 ± 4.3 nM). The mean concentration of 3-SPA in patients with AD treated with tramiprosate was 135 ± 51 nM. In vitro studies revealed a multi-ligand interaction of 3-SPA with monomeric Aβ42 that inhibits the aggregation of Aβ42 into small oligomers. Comparisons of the molecular interactions of tramiprosate and 3-SPA with Aβ42 are also presented. Furthermore, in rat preclinical studies, 3-SPA displayed 100% oral bioavailability and 25% brain penetration, indicating that the metabolite is well absorbed and crosses the blood-brain barrier.[1]
Alias3-SPA
Chemical Properties
Molecular Weight154.14
FormulaC3H6O5S
Cas No.44826-45-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 1.79 mg/mL (11.59 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM6.4876 mL32.4380 mL64.8761 mL324.3804 mL
5 mM1.2975 mL6.4876 mL12.9752 mL64.8761 mL
10 mM0.6488 mL3.2438 mL6.4876 mL32.4380 mL

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