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4-DAMP
🥰Excellent
Catalog No. T22511Cas No. 1952-15-4
Alias 4-DAMP methiodide
4-DAMP (4-DAMP methiodide) is a selective muscarinic M1 and M3 subtype receptor antagonist used in the study of allergic rhinitis and cardiovascular disease.
4-DAMP
🥰Excellent
Catalog No. T22511Alias 4-DAMP methiodideCas No. 1952-15-4
4-DAMP (4-DAMP methiodide) is a selective muscarinic M1 and M3 subtype receptor antagonist used in the study of allergic rhinitis and cardiovascular disease.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $148 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | 4-DAMP (4-DAMP methiodide) is a selective muscarinic M1 and M3 subtype receptor antagonist used in the study of allergic rhinitis and cardiovascular disease. |
| Targets&IC50 | muscarinic M5 receptor:8.9 (pKi), muscarinic M5 receptor:8.6 (pKB), muscarinic M3 receptor:8.8 (pKB), muscarinic M3 receptor:9.3 (pKi) |
| In vitro | 4-DAMP apparent affinities (pKB) at the muscarinic M3 receptor was 8.8, pKi=9.3. 4-DAMP apparent affinities (pKB) at the muscarinic M5 receptor was 8.6, pKi=8.9 . [1] |
| In vivo | An AR model was established by inducing male guinea pigs (4-6 weeks of age) with ovalbumin. 4-DAMP group animals were treated with ipratropium bromide (0.6 mg/kg) and 4-DAMP (0.12 or 0.6 mg/kg) by intranasal instillation per nostril daily.  The AR symptom scores and nasal secretion weights of animals treated with 4-DAMP were reduced significantly, goblet cell metaplasia was reversed, and eosinophil infiltration was visibly alleviated. [2] |
| Alias | 4-DAMP methiodide |
| Molecular Weight | 451.34 |
| Formula | C21H26INO2 |
| Cas No. | 1952-15-4 |
| Smiles | [I-].O=C(OC1CC[N+](C)(C)CC1)C(C=2C=CC=CC2)C=3C=CC=CC3 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (177.25 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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