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4-Hydroxyderricin
🥰Excellent
Catalog No. T10146Cas No. 55912-03-3
4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-hydroxylase (DBH) activity and possesses antidepressant activity.
4-Hydroxyderricin
🥰Excellent
Purity: 98%
Catalog No. T10146Cas No. 55912-03-3
4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-hydroxylase (DBH) activity and possesses antidepressant activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $122 | In Stock | |
| 5 mg | $298 | In Stock | |
| 10 mg | $447 | In Stock | |
| 25 mg | $738 | In Stock | |
| 50 mg | Inquiry | In Stock |
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Purity:98%
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Product Introduction
Bioactivity
Chemical Properties
| Description | 4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-hydroxylase (DBH) activity and possesses antidepressant activity. |
| Targets&IC50 | MAO-B:3.43 μM |
| In vitro | 4-Hydroxyderricin (100 microM) inhibited DNA synthesis in LLC cells, but it had no effect on the DNA synthesis in human umbilical vein endothelial cells (HUVECs) or on the adherence of LLC cells to HUVECs. 4-hydroxyderricin (50 mg/kg x 2/day) inhibited the reduction of the numbers of lymphocytes, CD4+, CD8+ and natural killer (NK)-T cells in the spleen of tumor-removed mice.[2] |
| In vivo | 4-Hydroxyderricin (50 mg/kg x 2/day; oral) inhibited the tumor growth in subcutaneous LLC-implanted mice and inhibited the lung metastasis and prolonged the survival time in mice after the removal of subcutaneous tumors by surgical operation.[2] 4-Hydroxyderricin (10 to 100 microM) inhibited Matrigel-induced formation of capillary-like tubes by HUVECs.[2] The weights of the spleen and thymus in mice with subcutaneously implanted LLC were maintained close to those of normal mice by orally administered 4-hydroxyderricin.[2] |
| Molecular Weight | 338.4 |
| Formula | C21H22O4 |
| Cas No. | 55912-03-3 |
| Smiles | COc1ccc(C(=O)\C=C\c2ccc(O)cc2)c(O)c1CC=C(C)C |
| Relative Density. | 1.181g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90.0 mg/mL (266.0 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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