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5-O-Demethylnobiletin
🥰Excellent
Catalog No. T5714Cas No. 2174-59-6
Alias 5-DEMETHYLNOBILETIN
5-O-Demethylnobiletin (5-DEMETHYLNOBILETIN) is a natual product, has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX-2.
5-O-Demethylnobiletin
🥰Excellent
Purity: 99.83%
Catalog No. T5714Alias 5-DEMETHYLNOBILETINCas No. 2174-59-6
5-O-Demethylnobiletin (5-DEMETHYLNOBILETIN) is a natual product, has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX-2.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $59 | In Stock | |
| 5 mg | $129 | In Stock | |
| 10 mg | $219 | In Stock | |
| 25 mg | $383 | In Stock | |
| 50 mg | $535 | In Stock | |
| 100 mg | $795 | In Stock | |
| 500 mg | $1,730 | In Stock |
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Purity:99.83%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 5-O-Demethylnobiletin (5-DEMETHYLNOBILETIN) is a natual product, has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX-2. |
| Targets&IC50 | LTC4:0.35 μM (IC50), 5-LOX:0.1 μM (IC50) |
| In vitro | 5-DEMETHYLNOBILETIN promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent signaling pathways[1]. |
| In vivo | 5-O-Demethylnobiletinreduced the oedema formation, cell infiltration, and tissue damage in the inflammation induced by TPA in mouse ears, along with the acute oedema induced by carrageenan in mouse paws and the acute PLA -induced oedema in mouse paws.The flavone inhibited leukotriene B formation in rat neutrophils and elastase release in human neutrophils, but did not reduce the expression of cyclooxygenase-2 (COX-2) in murine RAW 264.7 macrophages.These experimental results suggest that 5-O-Demethylnobiletinmay actthrough a direct inhibition of 5-LOX, without affecting the expression of COX-2[2]. |
| Alias | 5-DEMETHYLNOBILETIN |
| Molecular Weight | 388.37 |
| Formula | C20H20O8 |
| Cas No. | 2174-59-6 |
| Smiles | COc1ccc(cc1OC)-c1cc(=O)c2c(O)c(OC)c(OC)c(OC)c2o1 |
| Relative Density. | 1.304g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.88 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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