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6-Benzoylheteratisine
🥰Excellent
Catalog No. TN6713Cas No. 99759-48-5
Alias Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth
6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) is a Aconitum alkaloid. It can inhibits voltage-gated Na+ channels in rat brain synaptosomes
6-Benzoylheteratisine
🥰Excellent
Purity: 99.87%
Catalog No. TN6713Alias Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-methCas No. 99759-48-5
6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) is a Aconitum alkaloid. It can inhibits voltage-gated Na+ channels in rat brain synaptosomes
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $285 | In Stock | |
| 5 mg | $687 | In Stock | |
| 10 mg | $998 | In Stock | |
| 25 mg | $1,480 | In Stock | |
| 50 mg | $1,990 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $855 | In Stock |
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Purity:99.87%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) is a Aconitum alkaloid. It can inhibits voltage-gated Na+ channels in rat brain synaptosomes |
| In vitro | A concentration-dependent inhibitory effect of 6-benzoylheteratisine on aconitine-induced increases in [Na+]i, [Ca2+]i and the release of glutamate.?The IC50 values were 4.1 microM (Na+), 4.8 microM (Ca2+) and 4.8 microM (glutamate release).?Application of 100 microM 6-benzoylheteratisine after stimulation with 5 microM veratridine also reduced the induced [Na+]i and [Ca2+]i with half-lives of 72.1 and 44.7 s, respectively.?Furthermore, 100 microM 6-benzoylheteratisine reduced the ouabain-induced Na+ influx to the same extent as the Na+ channel inhibitor tetrodotoxin, which points to an inhibition of non-activated Na+ channels by 6-benzoylheteratisine.?Additionally, 100 microM 6-benzoylheteratisine failed to affect the release of glutamate and the increase in [Ca2+]i induced by 30 mM KCl, indicating that voltage-gated Ca2+ channels were not affected by 6-benzoylheteratisine.?The data suggest an inhibitory effect of 6-benzoylheteratisine on voltage-gated Na+ channels as the only target, whereas mechanisms of Na+ and Ca2+ homoeostasis and pathways of glutamate release seem not to be affected by the drug[1]. |
| Alias | Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth |
| Molecular Weight | 495.61 |
| Formula | C29H37NO6 |
| Cas No. | 99759-48-5 |
| Smiles | [H][C@]12[C@@H](OC(=O)c3ccccc3)[C@@]3([H])[C@]4([C@H](CC[C@@]3(C)CN(CC)[C@]14[H])OC)[C@]1([H])C[C@@H]3CC[C@@]2(O)[C@@]1([H])C(=O)O3 |
| Relative Density. | 1.32g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (50.44 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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