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AX20017

AX20017, a small-molecule protein kinase G (PknG) inhibitor (IC50: 0.39 μM), functions by inhibiting the proliferation of M. tuberculosis.

Catalog No. T7312Cas No. 329221-38-7

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Purity:99.31%

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COA HNMR LCMS

AX20017

Catalog No. T7312Cas No. 329221-38-7

AX20017, a small-molecule protein kinase G (PknG) inhibitor (IC50: 0.39 μM), functions by inhibiting the proliferation of M. tuberculosis.

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Pack Size	Price	Availability
5 mg	$39	In Stock
10 mg	$55	In Stock
25 mg	$119	In Stock
50 mg	$206	In Stock
100 mg	$310	In Stock
200 mg	$449	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock

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Product Introduction

Bioactivity

Description	AX20017, a small-molecule protein kinase G (PknG) inhibitor (IC50: 0.39 μM), functions by inhibiting the proliferation of M. tuberculosis.
Targets&IC50	PKNG:0.39 μM
In vitro	The inhibitory activity of AX20017 against the 11 known mycobacterial kinases revealed that the compound is highly selective for PknG . To test the activity of the inhibitor toward eukaryotic kinases, a screen of 28 different archetypical human kinases originating from six major protein kinase groups was set up. AX20017 did not affect the human kinases, whereas the activity of PknG was effectively inhibited[1].

Chemical Properties

Molecular Weight	264.34
Formula	C₁₃H₁₆N₂O₂S
Cas No.	329221-38-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 32 mg/mL (121.06 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7830 mL	18.9150 mL	37.8301 mL	189.1503 mL
5 mM	0.7566 mL	3.7830 mL	7.5660 mL	37.8301 mL
10 mM	0.3783 mL	1.8915 mL	3.7830 mL	18.9150 mL
20 mM	0.1892 mL	0.9458 mL	1.8915 mL	9.4575 mL
50 mM	0.0757 mL	0.3783 mL	0.7566 mL	3.7830 mL
100 mM	0.0378 mL	0.1892 mL	0.3783 mL	1.8915 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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