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Alpha-Estradiol

Catalog No. T3378 CAS 57-91-0

Synonyms: Alfatradiol, 17α-Estradiol, Epiestrol, Epiestradiol

Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia.

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Alpha-Estradiol, CAS 57-91-0

Pack Size	Availability	Price/USD
100 mg	In stock	$ 50.00
500 mg	In stock	$ 83.00
1 mL * 10 mM (in DMSO)	In stock	$ 55.00

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Purity: 99.69%

Purity: 99.61%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia.

Kinase Assay

Na+-Ca2+ exchange activity is determined by assaying Na+-dependent 45Ca2+ uptake as reported previously. Briefly, the cells are preincubated in Hanks' balanced saline solution (HBSS) for 20 min, and the medium is switched to HBSS containing 45Ca2+?and incubated for 5 min. To increase intracellular Na+?concentration, 1 mM ouabain plus 20 μM monensin (for astrocytes and microglia) and 10 μM monensin (for neurons) are used. Monensin is added simultaneously with the isotope. Ouabain is added 5 min before monensin in astrocytes and microglia. SEA0400 and KB-R7943 are added 5 min before monensin and present during 45Ca2+?uptake reaction.

Synonyms	Alfatradiol, 17α-Estradiol, Epiestrol, Epiestradiol
Molecular Weight	272.38
Formula	C18H24O2
CAS No.	57-91-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mM

Ethanol: 100 mM

References and Literature

1. Santos RS, et al. The effects of 17 alpha-estradiol to inhibit inflammation in vitro. Biol Sex Differ. 2017 Sep 6;8:30. 2. Schriefers H, et al. Inhibition of testosterone metabolism by 17-alpha-estradiol in rat liver slices. Arzneimittelforschung. 1991 Nov;41(11):1186-9. 3. Zhang HB, et al. 17-Alpha-estradiol ameliorating oxygen-induced retinopathy in a murine model. Jpn J Ophthalmol. 2012 Jul;56(4):407-15.

Related compound libraries

This product is contained In the following compound libraries：

Human Endogenous Metabolite Library Drug Repurposing Compound Library Bioactive Compound Library FDA-Approved Drug Library Approved Drug Library Bioactive Lipid Compound Library Natural Product Library for HTS Bioactive Compounds Library Max Metabolism Compound Library ReFRAME Related Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Alpha-Estradiol 57-91-0 Endocrinology/Hormones Metabolism Endogenous Metabolite Reductase Estrogen/progestogen Receptor 17a-Estradiol α-Estradiol a-Estradiol 5α-reductase 5 alpha Reductase Alfatradiol Inhibitor 17α-Estradiol Epiestrol Alpha Estradiol 17alpha-Estradiol inhibit AlphaEstradiol Epiestradiol inhibitor

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