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ALSTERPAULLONE

ALSTERPAULLONE
Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec
Catalog No. T7426Cas No. 237430-03-4
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Purity:99.39%
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ALSTERPAULLONE

Catalog No. T7426Cas No. 237430-03-4
Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$53In Stock
5 mg$118In Stock
10 mg$193In Stock
25 mg$329In Stock
50 mg$472In Stock
100 mg$653In Stock
200 mg$879In Stock
1 mL x 10 mM (in DMSO)$113In Stock
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Product Introduction

Bioactivity
Description
Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec
Targets&IC50
CDK5-p35:40 nM, CDK2-CyclinA:15 nMCD, K2/Cyc E:200 nM, CDK1-CyclinB:35 nM
In vitro
Alsterpaullone inhibited HeLa cells in a time-dependent (0-72 h) and dose-dependent (0-30 μ M) manner.?In the presence of alsterpaullone, HeLa cells were arrested in G2/M prior to undergoing apoptosis via a mechanism that is involved in the regulation of various antiapoptotic genes, DNA-repair, transcription, and cell cycle progression.?Compared to controls, alsterpaullone effectively prevented HeLa cells from entering S-phase.?These potential therapeutic efficacies could be correlated with the activation of caspase-3[1].
Chemical Properties
Molecular Weight293.28
FormulaC16H11N3O3
Cas No.237430-03-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 12 mg/mL (40.92 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.4097 mL17.0486 mL34.0971 mL170.4855 mL
5 mM0.6819 mL3.4097 mL6.8194 mL34.0971 mL
10 mM0.3410 mL1.7049 mL3.4097 mL17.0486 mL
20 mM0.1705 mL0.8524 mL1.7049 mL8.5243 mL

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