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Anandamide

Catalog No. T14046 CAS 94421-68-8

Synonyms: (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide

Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55) in the central nervous system.

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Anandamide, CAS 94421-68-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 36.00
2 mg	In stock	$ 53.00
5 mg	In stock	$ 79.00
10 mg	In stock	$ 157.00
25 mg	In stock	$ 297.00
50 mg	In stock	$ 458.00
100 mg	In stock	$ 673.00
500 mg	In stock	$ 1,430.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 98.76%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55) in the central nervous system.
In vitro	Anandamide, acting via CB2 receptors, alleviates lipopolysaccharide (LPS)-induced neuroinflammation in rat primary microglial cultures. Endocannabinoids, especially Anandamide (AEA), can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55 [1].
In vivo	Anandamide is an endocannabinoid binding both CB1R and CB2R. To evaluate the impact of CBR activation on whole-body glucose homeostasis, glucose tolerance is assessed after a single intraperitoneal Anandamide injection (10 mg/kg). The increase in glycemia in response to glucose ingestion is considerably smaller in mice treated with Anandamide compared with control. It is associated with an improvement of glucose tolerance as illustrated by the AUC0-2h calculations[2].

Synonyms	(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide
Molecular Weight	347.53
Formula	C22H37NO2
CAS No.	94421-68-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 10 mg/mL (28.77 mM)

DMSO: 250 mg/mL (719.36 mM)

References and Literature

1. Malek N, et al. Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures. Neural Plast. 2015;2015:130639. 2. Troy-Fioramonti S, et al. Acute activation of cannabinoid receptors by Anandamide reduces gastrointestinal motility and improves postprandial glycemia in mice. Diabetes. 2015 Mar;64(3):808-18.

Related compound libraries

This product is contained In the following compound libraries：

Human Endogenous Metabolite Library Membrane Protein-targeted Compound Library GPCR Compound Library Natural Product Library ReFRAME Related Library NO PAINS Compound Library Human Endogenous Metabolite Compound Library Plus Human Metabolite Library Immunology/Inflammation Compound Library Natural Product Library for HTS

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Anandamide 94421-68-8 GPCR/G Protein Metabolism Cannabinoid Receptor Endogenous Metabolite Transient receptor potential channels Inhibitor inhibit Alzheimer’s disease Candida albicans anti-fungal anti-adhesive cervical epithelial cells G protein-coupled receptor 55 Streptozotocin (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide hVSMC N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide HeLa cells GPR55 TRP Channel endocannabinoid Peroxisome proliferator-activated receptors Fungal PPAR Tau Protein inhibitor

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