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Atezolizumab

Catalog No. T9902 CAS 1380723-44-3

Atezolizumab anti-PD-L1) is a fully humanized IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1 but not the interaction of PD-L2 with PD-1.

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Atezolizumab, CAS 1380723-44-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 229.00
5 mg	In stock	$ 543.00
10 mg	In stock	$ 797.00

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AntibodyUnit: 57.5 mg/mL

Purity: 95.20%

AntibodyUnit: 59 mg/mL

Purity: 95.10%

AntibodyUnit: 61 mg/mL

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Storage & Solubility Information

Description

Atezolizumab anti-PD-L1) is a fully humanized IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1 but not the interaction of PD-L2 with PD-1.

Cell Research

Objective: Determine the binding of [111In]PD-L1-mAb to tumor cell lines. Cells: NCI-H2444（Lung Cancer cell line）, MDAMB231（Breast Cancer cell line）,etc. Concentrations: 1 μCi/100μl. Incubation Time: 1 h. Method: Incubating 1 μCi of [111In]PD-L1-mAb with 1×106cells (in triplicate for each cell line) for 1h at 37°C. PD-L1 blocking was performed by adding a 10-fold molar equivalent excess of the non-labeled mAb. After incubation, cells were washed three times with cold PBS prior to counting on an automated gamma counter.

Molecular Weight	145 kDa
CAS No.	1380723-44-3

Storage

store at low temperature

store at -20°C

References and Literature

1. Inman BA, et al. Atezolizumab: A PD-L1-Blocking Antibody for Bladder Cancer. Clin Cancer Res. 2017 Apr 15;23(8):1886-1890. 2. Deng R, et al. Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor. MAbs. 2016;8(3):593-603. 3. Zheng Y, et al. Combining MPDL3280A with adoptive cell immunotherapy exerts better antitumor effects against cervical cancer. Bioengineered. 2017 Jul 4;8(4):367-373. 4. Herbst RS, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature. 2014 Nov 27;515(7528):563-7.

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Keywords

Atezolizumab 1380723-44-3 Apoptosis Autophagy Cell Cycle/Checkpoint Immunology/Inflammation PD-1/PD-L1 Inhibitor MPDL3280A inhibit inhibitor

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