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Atglistatin

Catalog No. T1875   CAS 1469924-27-3

Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when the concentration up to 50 μM.

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Atglistatin Chemical Structure
Atglistatin, CAS 1469924-27-3
Pack Size Availability Price/USD Quantity
2 mg In stock $ 34.00
5 mg In stock $ 55.00
10 mg In stock $ 105.00
25 mg In stock $ 198.00
50 mg In stock $ 369.00
100 mg In stock $ 583.00
500 mg In stock $ 1,250.00
1 mL * 10 mM (in DMSO) In stock $ 61.00
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Purity: 99.81%
Purity: 99.33%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when the concentration up to 50 μM.
Targets&IC50 ATGL:0.7 μM
Kinase Assay Determination of lipase activity: For determination of lipase activity, lysates are incubated with a substrate containing radiolabeled [9,10-3H(N)]-triolein. Subsequently, FA are extracted and quantitated by liquid scintilation counting. Data are presented as mean S.D. of triplicate determinations and representative for at least three independent experiments.
Cell Research For MTT-based in vitro viability assays, cells are seeded in 96-well plates and cultured under standard conditions for 24 h. The next day, cells are pretreated with different concentrations of Atglistatin dissolved in DMSO or Cisplatin dissolved in DMF as positive control for 2 h. Medium is replaced by an identical fresh medium and incubated again for the indicated time points. Thereafter, cells are incubated for 3 h with 100 μL Thiazolyl Blue Tetrazolium Bromide (MTT). The resulting violet formazan crystals are dissolved by adding 100 μL of MTT solubilization solution (0.1% NP-40, 4 mM HCl and anhydrous isopropanol). After complete dissolution of the formazan product, absorbance is measured at 595 nm using 690 nm as reference wavelength.(Only for Reference)
Molecular Weight 283.37
Formula C17H21N3O
CAS No. 1469924-27-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 52 mg/mL (183.5 mM)

Ethanol: 4 mg/mL (14.11 mM)

TargetMolReferences and Literature

1. Mayer N, et al. Nat Chem Biol. 2013, 9(12), 785-787.

TargetMolCitations

1. Bottermann K, Kalfhues L, Nederlof R, et al. Cardiomyocyte p38 MAPKα suppresses a heart–adipose tissue–neutrophil crosstalk in heart failure development. Basic Research in Cardiology. 2022, 117(1): 1-21. 2. Li M, Yang J, Ye C, et al. Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells during JEV Infection. Virologica Sinica. 2021: 1-12.

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Anti-Metabolism Disease Compound Library Anti-Aging Compound Library Bioactive Lipid Compound Library Lipid Metabolism Compound Library Anti-Obesity Compound Library Bioactive Compounds Library Max Inhibitor Library Target-Focused Phenotypic Screening Library Bioactive Compound Library

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Keywords

Atglistatin 1469924-27-3 Metabolism Lipase ATGL inhibit Adipose triglyceride lipase Inhibitor inhibitor

 

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