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BMS-906024
🥰Excellent
Catalog No. T14680Cas No. 1401066-79-2
Alias Osugacestat, BM-0018, AL-101
BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-906024 prevents the activation of all four Notch receptors, and is active against Notch1, -2, -3 and -4 receptors. BMS-906024 prevents the activation of all four Notch receptors, with IC50s of 1.6, 0.7, 3.4 and 2.9 nM for Notch1, -2, -3 and -4 receptors, respectively.
BMS-906024
🥰Excellent
Purity: 100%
Catalog No. T14680Alias Osugacestat, BM-0018, AL-101Cas No. 1401066-79-2
BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-906024 prevents the activation of all four Notch receptors, and is active against Notch1, -2, -3 and -4 receptors. BMS-906024 prevents the activation of all four Notch receptors, with IC50s of 1.6, 0.7, 3.4 and 2.9 nM for Notch1, -2, -3 and -4 receptors, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $565 | In Stock | |
| 2 mg | $788 | In Stock | |
| 5 mg | $1,180 | In Stock | |
| 10 mg | $1,790 | In Stock | |
| 25 mg | $2,680 | In Stock | |
| 50 mg | $3,620 | In Stock | |
| 100 mg | $4,880 | In Stock |
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CitedSelect Batch
Purity:100%
ee:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-906024 prevents the activation of all four Notch receptors, and is active against Notch1, -2, -3 and -4 receptors. BMS-906024 prevents the activation of all four Notch receptors, with IC50s of 1.6, 0.7, 3.4 and 2.9 nM for Notch1, -2, -3 and -4 receptors, respectively. |
| Targets&IC50 | Notch4:2.9 nM, Notch2:0.7 nM, Notch1:1.6 nM, Notch3:3.4 nM |
| In vitro | BMS-906024 (100 nM; 72 h) is an effective Notch activation inhibitor, which enhances the in vitro anti-tumor activity of paclitaxel[1]. |
| Alias | Osugacestat, BM-0018, AL-101 |
| Molecular Weight | 556.5 |
| Formula | C26H26F6N4O3 |
| Cas No. | 1401066-79-2 |
| Smiles | CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C1=O)c1ccccc1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (8.98 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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