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BMT-145027

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Purity:99.5%

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COA LCMS HNMR

BMT-145027

Catalog No. T10573Cas No. 2018282-44-3

BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM).

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Pack Size	Price	Availability
1 mg	$38	In Stock
2 mg	$55	In Stock
5 mg	$93	In Stock
10 mg	$157	In Stock
25 mg	$262	In Stock
50 mg	$371	In Stock
100 mg	$475	In Stock
500 mg	$978	In Stock

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Product Introduction

Bioactivity

Description	BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM).
In vitro	BMT-145027 lacks inherent mGluR5 agonist activity when tested at concentrations up to 16 μM. BMT-145027 exhibits high MsLM stability (85% remaining) and a modest decrease in planarity (Fsp3 = 0.17)[1].
In vivo	BMT-145027 (30 mg/kg) leads to a significant increase in time spent with the novel object, with an apparent trend in novel object preference at 10 mg/kg. Satellite animals(BMT-145027: 30 mg/kg) indicates a total plasma concentration of 2800 nM[1].

Chemical Properties

Molecular Weight	438.83
Formula	C23H14ClF3N4
Cas No.	2018282-44-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2 mg/mL (4.56 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2788 mL	11.3939 mL	22.7879 mL	113.9393 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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