Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 80.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 339.00 | |
25 mg | In stock | $ 576.00 | |
50 mg | In stock | $ 825.00 | |
100 mg | In stock | $ 1,130.00 | |
500 mg | In stock | $ 2,290.00 |
Description | BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM). |
Targets&IC50 | mGluR5:47 nM |
In vitro | BMT-145027 lacks inherent mGluR5 agonist activity when tested at concentrations up to 16 μM. BMT-145027 exhibits high MsLM stability (85% remaining) and a modest decrease in planarity (Fsp3 = 0.17)[1]. |
In vivo | BMT-145027 (30 mg/kg) leads to a significant increase in time spent with the novel object, with an apparent trend in novel object preference at 10 mg/kg. Satellite animals(BMT-145027: 30 mg/kg) indicates a total plasma concentration of 2800 nM[1]. |
Molecular Weight | 438.83 |
Formula | C23H14ClF3N4 |
CAS No. | 2018282-44-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2 mg/mL (4.56 mM), sonification/heating is recommended.
You can also refer to dose conversion for different animals. More
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BMT-145027 2018282-44-3 Neuroscience GluR Inhibitor mGluR inhibit BMT145027 BMT 145027 Metabotropic glutamate receptors inhibitor