Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BN82002 (CDC25 Phosphatase Inhibitor I) is a synthetic inhibitor of CDC25 phophatases
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 222.00 | |
50 mg | In stock | $ 372.00 | |
100 mg | In stock | $ 556.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 98.00 |
Description | BN82002 (CDC25 Phosphatase Inhibitor I) is a synthetic inhibitor of CDC25 phophatases |
Targets&IC50 | CDC25B2:3.9 μM, CDC25A:2.4 μM, CDC25B3:6.3 μM, CDC25C:5.4 μM, CDC25C-cat:4.6 μM |
In vitro | The in vitro impact of BN82002 on the proliferation of various human tumor cell lines has been assessed, with menadione serving as a control due to its documented proliferation inhibitory properties. All tested cell lines exhibit sensitivity to both BN82002 and menadione, demonstrating concentration-dependent inhibition within the low micromolar range. Among these, the pancreatic cancer cell line MIA PaCa-2 is the most affected by BN82002, showing an IC50 of 7.2 μM, while the colon cancer cell line HT-29 shows the least sensitivity with an IC50 of 32.6 μM. This range of inhibitory concentration for BN82002 closely matches that observed with menadione (5-15 μM). Further findings indicate that a 50 μM concentration of BN82002 completely halts cell proliferation. Although the influence on cell cycle distribution is relatively mild, there is a noted decrease in the S phase and an increase in cells with G1 and G2 DNA content, hinting at cell cycle arrest at various stages due to BN82002 treatment. |
Synonyms | CDC25 Phosphatase Inhibitor I |
Molecular Weight | 359.42 |
Formula | C19H25N3O4 |
CAS No. | 396073-89-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 150 mg/mL (417.34 mM)
You can also refer to dose conversion for different animals. More
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BN82002 396073-89-5 Metabolism Phosphatase CDC25C CDC25A inhibit BN 82002 CDC25B3 MIA PaCa-2 Inhibitor CDC25B2 BN-82002 CDC25 Phosphatase Inhibitor I inhibitor