Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BPH-1358 (NSC-50460) (NSC-50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor. With IC50s of 1.8 μM and 110 nM, respectively. And it is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 133.00 | |
5 mg | In stock | $ 302.00 | |
10 mg | In stock | $ 453.00 | |
25 mg | In stock | $ 680.00 | |
50 mg | In stock | $ 1,020.00 | |
100 mg | In stock | $ 1,370.00 | |
500 mg | In stock | $ 2,730.00 |
Description | BPH-1358 (NSC-50460) (NSC-50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor. With IC50s of 1.8 μM and 110 nM, respectively. And it is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2]. |
Targets&IC50 | human bisphosphonate farnesyl diphosphate synthase:1.8 μM |
In vitro | BPH-1358 against E. coli and S. aureus with EC50 of 300 nM and 290 nM, respectively[1]. BPH-1358 is the most potent inhibitor of both E. coli UPPS (EcUPPS) as well as S. aureus UPPS (SaUPPS), with an IC50 of 110 nM. |
In vivo | BPH-1358 is active against S. aureus in vivo (20/20 mice survived an intraperitoneal infection model of MRSA strain)[1]. |
Synonyms | NSC50460 |
Molecular Weight | 601.53 |
Formula | C32H30Cl2N6O2 |
CAS No. | 5352-53-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Slightly soluble
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BPH-1358 5352-53-4 Microbiology/Virology Others Antibacterial Bacterial BPH 1358 inhibit Inhibitor NSC50460 BPH1358 NSC-50460 NSC 50460 inhibitor