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Burixafor hydrobromide

Catalog No. T10635   CAS 1191450-19-7
Synonyms: TG-0054 hydrobromide

Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent CXCR4 antagonist and an anti-angiogenic drug that is of potential value in treating choroid neovascularization.

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Burixafor hydrobromide Chemical Structure
Burixafor hydrobromide, CAS 1191450-19-7
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent CXCR4 antagonist and an anti-angiogenic drug that is of potential value in treating choroid neovascularization.
In vitro Burixafor hydrobromide mobilizes mesenchymal stem cells, attenuates inflammation, and preserves cardiac systolic function in a porcine model of myocardial infarction [2].
Synonyms TG-0054 hydrobromide
Molecular Weight 647.644
Formula C27H52BrN8O3P
CAS No. 1191450-19-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (65.02 mM), sonification is recommended.

TargetMolReferences and Literature

1. Shelke NB, et al. Intravitreal Poly(L-lactide) Microparticles Sustain Retinal and Choroidal Delivery of TG-0054, a Hydrophilic Drug Intended for Neovascular Diseases. Drug Deliv Transl Res. 2011 Feb;1(1):76-90. 2. Hsu WT, et al. CXCR4 Antagonist TG-0054 Mobilizes Mesenchymal Stem Cells, Attenuates Inflammation, and Preserves Cardiac Systolic Function in a Porcine Model of Myocardial Infarction. Cell Transplant. 2015;24(7):1313-28.

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Navarixin TAK-779 AZD8797 AZD-5069 MSX-122 DOTA-CXCR4-L Nicotinamide N-oxide Plerixafor octahydrochloride

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Keywords

Burixafor hydrobromide 1191450-19-7 Autophagy GPCR/G Protein Immunology/Inflammation CXCR TG 0054 Hydrobromide TG-0054 Hydrobromide TG0054 Hydrobromide Burixafor Hydrobromide TG-0054 hydrobromide inhibitor inhibit

 

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