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CB1 inverse agonist 1

Catalog No. T10694 CAS 852315-00-5

Synonyms: MRL-650

CB1 inverse agonist 1 (MRL-650) is an orally active and selective CB1 agonist. The IC50s for CB1 and CB2 are 7.5 nM and 4100 nM, respectively. CB1 inverse agonist 1 shows anorexigenic effects.

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CB1 inverse agonist 1 Chemical Structure

CB1 inverse agonist 1, CAS 852315-00-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 447.00
10 mg	In stock	$ 659.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,380.00
100 mg	In stock	$ 1,890.00
500 mg	In stock	$ 3,790.00
1 mL * 10 mM (in DMSO)	In stock	$ 547.00

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Purity: 99.12%

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Description	CB1 inverse agonist 1 (MRL-650) is an orally active and selective CB1 agonist. The IC50s for CB1 and CB2 are 7.5 nM and 4100 nM, respectively. CB1 inverse agonist 1 shows anorexigenic effects.
Targets&IC50	CB2:4100 nM, CB1:7.5 nM
In vivo	CB1 inverse agonist 1 (0.3-3 mg/kg) dose-dependently inhibits feeding in a manner[1].

Synonyms	MRL-650
Molecular Weight	514.79
Formula	C25H18Cl3N3O3
CAS No.	852315-00-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (87.41 mM)

References and Literature

1. Debenham JS, et al. Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists.Bioorg Med Chem Lett. 2006 Feb;16(3):681-5.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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N-Oleoyl glycine CB1 antagonist 1 CB2R agonist 2 CID 16020046 GW 833972A yangonin Rimonabant hydrochloride CB 65

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Keywords

CB1 inverse agonist 1 852315-00-5 GPCR/G Protein Cannabinoid Receptor MRL 650 MRL-650 MRL650 inhibitor inhibit

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