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Castanospermine

Catalog No. TQ0308 CAS 79831-76-8

Synonyms: 1,6,7,8-Tetrahydroxyoctahydroindolizine, (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyindolizidine

Castanospermine (1,6,7,8-Tetrahydroxyoctahydroindolizine) is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l.

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Castanospermine, CAS 79831-76-8

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5 mg	In stock	$ 32.00
10 mg	In stock	$ 52.00
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Purity: 99.74%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Castanospermine (1,6,7,8-Tetrahydroxyoctahydroindolizine) is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l.
In vitro	Castanospermine is a potent and specific inhibitor of mammalian and plant α-and β-D-glucosidases in vitro [1].
In vivo	Experiments in vivo with castanospermine, an inhibitor of the glucosidases that convert protein N-linked high mannose carbohydrates to complex oligosaccharides, resulted in significant inhibition of tumor growth in nude mice [3].
Source	Natural Products > Fagaceae > Castanea

Synonyms	1,6,7,8-Tetrahydroxyoctahydroindolizine, (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyindolizidine
Molecular Weight	189.21
Formula	C8H15NO4
CAS No.	79831-76-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 32 mg/mL (169.12 mM)

References and Literature

1. Bryan G, Anthony C et al. The structural basis of the inhibition of human glycosidases by castanospermine analogues. Biochem. J. (1990) 269, 227-231. 2. Eisaku Tsujii et al. Nectrisine Is a Potent Inhibitor of a-Glucosidases, Demonstrating Activities Similarly at Enzyme and Cellular Levels. Biochemical and Biophysical Research Communications 220, 459-466 (1996) 3. Pili R et al. The alpha-glucosidase I inhibitor castanospermine alters endothelial cell glycosylation, preventsangiogenesis, and inhibits tumor growth. Cancer Res. 1995 Jul 1;55(13):2920-6.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library NO PAINS Compound Library Bioactive Compound Library Natural Product Library for HTS Bioactive Compounds Library Max Anti-Infection Compound Library Kinase Inhibitor Library Glycometabolism Compound Library Anti-Viral Compound Library

Related Products

Related compounds with same targets

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Castanospermine 79831-76-8 Metabolism Glucosidase 1,6,7,8-Tetrahydroxyoctahydroindolizine inhibit Inhibitor (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyindolizidine inhibitor

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