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Centrinone

Catalog No. T14927 CAS 1798871-30-3

Synonyms: LCR-263

Purity 98.00% Datasheet

Centrinone (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).

Centrinone, CAS 1798871-30-3

Pack Size	Availability	Price/USD
2 mg	inquiry	98.00
5 mg	inquiry	146.00
10 mg	inquiry	239.00
50 mg	inquiry	971.00
100 mg	inquiry	1763.00
200 mg	inquiry	inquiry
500 mg	inquiry	inquiry
1 mL * 10 mM (in DMSO)	inquiry	202.00

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Purity 98.00%

Datasheet

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Centrinone (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).
Targets&IC50	PLK4 :ic50 0.16 nM （ki）, PLK4 G95L :ic50 68.57 nM （ki）, Aurora A :ic50 171 nM （ki）, Aurora B :ic50 436.76 nM （ki）,
In vitro	Centrinone treatment causes centrosome depletion in human and other vertebrate cells and reduces centriole number in multiciliated Xenopus epithelial cells. Centrinone treatment of HeLa human cervical carcinoma cells leads to a progressive reduction in foci containing centriolar and pericentriolar material markers at each round of cell division until most cells lack centrioles and centrosomes. Centrosome loss irreversibly arrests normal cells in a senescence-like G1 state by a p53-dependent mechanism that is independent of DNA damage, stress, Hippo signaling, extends mitotic duration, or segregation errors.

Synonyms	LCR-263
Purity	98.00%
Molecular Weight	633.65
Formula	C26H25F2N7O6S2
CAS No.	1798871-30-3

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 31 mg/mL (48.92 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Wong YL. et al. Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science. 2015 Jun 5;348(6239):1155-60.

Related Products

Related compounds with same targets

SP-146 Aurora Kinase Inhibitor III SNS-314 Mesylate Aurora inhibitor 1 SCH-1473759 AZD1152 MBM-17S MBM-17

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.