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Clofilium tosylate

Catalog No. T14982Cas No. 92953-10-1

Clofilium tosylate is a potassium channel blocker, induces apoptosis on human promyelocytic leukemia (HL-60) cells.

Clofilium tosylate

Clofilium tosylate

Purity: 99.68%
Catalog No. T14982Cas No. 92953-10-1
Clofilium tosylate is a potassium channel blocker, induces apoptosis on human promyelocytic leukemia (HL-60) cells.
Pack SizePriceAvailabilityQuantity
2 mg$30In Stock
5 mg$48In Stock
10 mg$80In Stock
25 mg$169In Stock
50 mg$315In Stock
100 mg$471In Stock
1 mL x 10 mM (in DMSO)$55In Stock
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Purity:99.68%
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Product Introduction

Bioactivity
Description
Clofilium tosylate is a potassium channel blocker. It induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3.
In vitro
Treatment with 0-20 μM Clofilium inhibits viability and proliferation in a time- and concentration-dependent manner in HL-60 cells. Cell viability is significantly reduced in HL-60 cells treated with 2.5 μM to 10 μM Clofilium After 12 hours. Treatment with 10 μM Clofilium induces the proteolytic cleavage of inactive procaspase-3, p34 into its active form, p17 and subsequent cleavage of its substrate PARP.. However, the expression of Bcl-2 and Bax proteins does not change significantly[1].
Chemical Properties
Molecular Weight510.17
FormulaC28H44ClNO3S
Cas No.92953-10-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (196.01 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9601 mL9.8007 mL19.6013 mL98.0065 mL
5 mM0.3920 mL1.9601 mL3.9203 mL19.6013 mL
10 mM0.1960 mL0.9801 mL1.9601 mL9.8007 mL
20 mM0.0980 mL0.4900 mL0.9801 mL4.9003 mL
50 mM0.0392 mL0.1960 mL0.3920 mL1.9601 mL
100 mM0.0196 mL0.0980 mL0.1960 mL0.9801 mL

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