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Clofilium tosylate

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Purity:99.68%

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COA HNMR HPLC

Clofilium tosylate

Catalog No. T14982Cas No. 92953-10-1

Clofilium tosylate is a potassium channel blocker, induces apoptosis on human promyelocytic leukemia (HL-60) cells.

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Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$48	In Stock
10 mg	$80	In Stock
25 mg	$169	In Stock
50 mg	$315	In Stock
100 mg	$471	In Stock
1 mL x 10 mM (in DMSO)	$55	In Stock

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Product Introduction

Bioactivity

Description

Clofilium tosylate is a potassium channel blocker. It induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3.

In vitro

Treatment with 0-20 μM Clofilium inhibits viability and proliferation in a time- and concentration-dependent manner in HL-60 cells. Cell viability is significantly reduced in HL-60 cells treated with 2.5 μM to 10 μM Clofilium After 12 hours. Treatment with 10 μM Clofilium induces the proteolytic cleavage of inactive procaspase-3, p34 into its active form, p17 and subsequent cleavage of its substrate PARP.. However, the expression of Bcl-2 and Bax proteins does not change significantly[1].

Chemical Properties

Molecular Weight	510.17
Formula	C28H44ClNO3S
Cas No.	92953-10-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (196.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9601 mL	9.8007 mL	19.6013 mL	98.0065 mL
5 mM	0.3920 mL	1.9601 mL	3.9203 mL	19.6013 mL
10 mM	0.1960 mL	0.9801 mL	1.9601 mL	9.8007 mL
20 mM	0.0980 mL	0.4900 mL	0.9801 mL	4.9003 mL
50 mM	0.0392 mL	0.1960 mL	0.3920 mL	1.9601 mL
100 mM	0.0196 mL	0.0980 mL	0.1960 mL	0.9801 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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