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DFP00173

Catalog No. T11014 CAS 672286-03-2

DFP00173 is a potent and selective aquaporin 3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with IC50 of ~0.1-0.4 μM. Compared with the homologous AQP subtypes AQP7 and AQP9, DFP00173 is selective for AQP3.

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DFP00173, CAS 672286-03-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	DFP00173 is a potent and selective aquaporin 3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with IC50 of ~0.1-0.4 μM. Compared with the homologous AQP subtypes AQP7 and AQP9, DFP00173 is selective for AQP3.
Targets&IC50	AQP3:0.1-0.4 μM
In vitro	DFP00173 inhibits the glycerol permeability of human red blood cells with IC50 of ~0.2 μM.

Molecular Weight	332.16
Formula	C11H7Cl2N3O3S
CAS No.	672286-03-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 124 mg/mL (373.31 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Sonntag Y, et al. Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors. J Biol Chem. 2019 May 3;294(18):7377-7387.

Related Products

Related compounds with same targets

AER-271 TGN-020 TC-AQP1-1 p-Tolylmaleimide DFP00173

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

DFP00173 672286-03-2 离子通道 Aquaporin AQP Inhibitor human isoforms erythrocytes selective homologous DFP 00173 glycerol DFP-00173 inhibit permeability inhibitor

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