Search Result

Search Results for " isoforms "

Targets

Aquaporin

161

Compounds

Natural Products

398

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T11014	DFP00173		Aquaporin
	DFP00173 is a potent and selective aquaporin 3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with IC50 of ~0.1-0.4 μM. Compared with the homologous AQP subtypes AQP7 and AQP9, DFP00173 is selective for AQP3.		Aquaporin
T7696	3-Cyano-7-ethoxycoumarin		Others
	3-Cyano-7-ethoxycoumarin is cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 .		Others
T79607	H-NTPDase-IN-2	hNTPDase-IN-2	Phosphatase
	h-NTPDase-IN-2 is a broad-spectrum NTPDase inhibitor that inhibits multiple h-NTPDas isoforms.		Phosphatase
T2458	CID755673		Serine/threonin kinase
	CID755673 is an effective and specific cell-active inhibitor for PKD (IC50: 182 nM); exhibits selective PKD1 inhibition when compared with PLK1, AKT, CAMKIIα, CAK, and PKC isoforms.		Serine/threonin kinase
T9904	Bevacizumab		VEGFR
	Bevacizumab, a humanized monoclonal antibody, specifically and with high affinity binds to all isoforms of VEGF-A.		VEGFR
T16129	MPI_5a		HDAC
	MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms and it also inhibits acyl-tubulin accumulation in cells (IC50: 210 nM).		HDAC
T12310	ON 146040	ZINC211117138	PI3K , Bcr-Abl
	ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.		PI3K , Bcr-Abl
T14841	BVT948		Phosphatase , P450 , Histone Methyltransferase
	BVT948 is a protein tyrosine phosphatase (PTP) inhibitor. It can also inhibit several CYP450 isoforms and lysine methyltransferase SETD8 (KMT5A).		Phosphatase , P450 , Histone Methyltransferase
T9788	SN32976		PI3K
	SN32976 is a pan PI3K inhibitor. SN32976 potently inhibited PI3K isoforms and mTOR, displaying preferential activity for PI3Kα and sparing of PI3Kδ.		PI3K
T21996	Zoniporide hydrochloride	CP-597396 hydrochloride	Sodium Channel
	Zoniporide hydrochloride is a selective inhibitor of NHE-1 with IC50 of 14 nM which is >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride shows an IC50 of 59 nM for NHE-1-dependent swelling of huma...		Sodium Channel
T21700	NOS-IN-1	2-Imino-4-methylpiperidine (acetate)	NOS
	NOS-IN-1 (2-Imino-4-methylpiperidine acetate) is a potent and orally active inhibitor of NO synthase (NOS) isoforms. NOS-IN-1 exhibits IC50s of 0.1 μM, 0.2 μM, and 1.1μM for human iNOS (hiNOS), hnNOS and heNOS, respectiv...		NOS
T1988	Duvelisib	INK1197,IPI-145	PI3K
	Duvelisib (INK1197) is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic a...		PI3K
T1859	AZD-8055		Apoptosis , mTOR , Autophagy
	AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.		Apoptosis , mTOR , Autophagy
T8182L	Guan-fu base A hydrochloride(1394-48-5 free base)		P450
	Guan-fu base A hydrochloride is an antiarrhythmic alkaloid was isolated from Aconitum coreanum. Guanfu base A is hydrochloride a CYP2D6 inhibitor of human, monkey, and dog isoforms.		P450
T7205	A-967079		TRP/TRPV Channel
	A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively.		TRP/TRPV Channel
T22336	Galloflavin		Dehydrogenase
	Galloflavin inhibits both the A and B isoforms of lactate dehydrogenase with Ki of 5.46 µM and 15.06 µM, respectively. Galloflavin is also a potential anticancer agent.		Dehydrogenase
T6054	GSK256066		PDE
	GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.Phase 2.		PDE
T76672	Aprutumab	FGFR-moAb,FGFR2-TTC,BAY 1179470	FGFR
	Aprutumab (BAY 1179470) is a human FGFR2 monoclonal antibody with affinity to FGFR2 isoforms FGFR2-IIIB and FGFR2-IIIC. Aprutumab is commonly used to synthesize antibody-drug conjugates.		FGFR
T7543	S-(2-aminoethyl) Isothiourea (dihydrobromide)		NOS
	S-(2-aminoethyl) Isothiourea (dihydrobromide) is a non-selective inhibitor of all NOS isoforms. For human nNOS, eNOS, and iNOS, the Ki values are 1.8, 2.1, and 0.59 µM, respectively		NOS
T1499	Dutasteride	GG 745,Avodart,GI 198745	Apoptosis , Reductase
	Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia.		Apoptosis , Reductase
T16760	RK-24466	KIN 001-51	Src
	RK-24466 (KIN 001-51) is a selective and potent inhibitor of Lck, inhibits Lck (64-509) and LckCD isoforms with IC50s of less than 1 and 2 nM, respectively.		Src
T7015	Vps34-IN-1	VPS34-IN1	PI3K , Autophagy
	Vps34-IN-1 (VPS34-IN1) is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM in vitro, which does not significantly inhibit the isoforms of class I as well as class II PI3Ks.		PI3K , Autophagy
T7474	7-Nitroindazole		NOS
	7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS.		NOS
T27643	Izonsteride	LY-320236,LY320236,UNII-A5E8C36F34	Reductase
	Izonsteride (LY320236) is a selective and potent 5alpha reductase inhibitor with dual action on the type I and type II isoforms of the enzyme.Izonsteride is used in the treatment of oncology and genitourinary disorders, ...		Reductase
T117521	7-BFC	7-Benzyloxy-4-(trifluoromethyl)coumarin,Y040-0031	P450
	7-BFC (7-Benzyloxy-4-(trifluoromethyl)coumarin) is a coumarin-like fluorescent substrate that serves as a biomarker for cytochrome P 450 and can be used to study CYP isoforms and cytochrome P 450 metabolism.		P450
T72032	PI5P4Ks-IN-2		PI3K
	PI5P4Ks-IN-2 is an inhibitor of the phosphatidylinositol 5-phosphate 4-kinase PI5P4Kγ. Targeting the PI5P4K isoforms, PI5P4Ks-IN-2 inhibited PI5P4Kα, PI5P4Kβ, PI5P4Kγ, and PI5P4Kγ+, with IC50 values of <4.3, <4.6, 6.2, a...		PI3K
T14983	Clomethiazole	Distraneurin,Chlormethiazole,5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE	P450 , GABA Receptor
	Clomethiazole (Distraneurin) is an orally active GABAA agonist and it is an anticonvulsant agent. It also has the potential for treating convulsive status epilepticus. Chlormethiazole inhibits cytochrome P450 isoforms: C...		P450 , GABA Receptor
T0961	Trometamol	Tromethamine	COX
	Trometamol (Tromethamine) is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachidonic acid to pro-inflammatory pro-prostagland...		COX
T6976	SB 239063	SB239063	p38 MAPK , Autophagy
	SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.		p38 MAPK , Autophagy
T15697	L-NMMA acetate	Tilarginine acetate,Methylarginine acetate	NOS
	L-NMMA acetate (Tilarginine acetate) is an inhibitor of nitric oxide synthase of all NOS isoforms (i.e. NOS1, NOS2, and NOS3). The Ki values are 0.18, 0.4, and 6 µM for nNOS, eNOS, and iNOS, respectively.		NOS
T15550	IDH-305		Dehydrogenase
	IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor. IDH-305 shows greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC50s: 27 nM (IDH1R132H), 28 nM (IDH1R132C), 6.14 µM (...		Dehydrogenase
T13140	Umbralisib R-enantiomer	TGR-1202 R-enantiomer,RP5264 R-enantiomer	PI3K
	Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202. The IC50 of Umbralisib R-enantiomers against δPI3 kinase is at least 20 times lower than that of the in...		PI3K
T6883	Samotolisib	GTPL8918,LY3023414	DNA-PK , PI3K , mTOR , Autophagy
	Samotolisib (LY3023414) is an oral ATP competitive inhibitor of the class I PI3K isoforms, DNA-PK, and mTOR. Samotolisib (LY3023414) has been used in trials studying the treatment of Neoplasm, Solid Tumor, COLON CANCER, ...		DNA-PK , PI3K , mTOR , Autophagy
T0196	Diclofenac	Diclofenacum,Voltaren	Apoptosis , COX
	Diclofenac (Diclofenacum) is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of a...		Apoptosis , COX
T72918	JNJ-49095397	RV568
	JNJ-49095397 (RV568), an inhaled narrow-spectrum kinase inhibitor (NSKI), targets the α and γ isoforms of p38 MAPK and the SRC kinase family, particularly haematopoietic kinase (HCK). Demonstrating potent anti-inflammato...
T6927	Pamapimod	R1503,Ro4402257	p38 MAPK , Autophagy
	Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectiv...		p38 MAPK , Autophagy
T2078	Fimepinostat	CUDC-907,PI3K/HDAC Inhibitor,CUDC 907	Apoptosis , PI3K , HDAC
	Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan-histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, C...		Apoptosis , PI3K , HDAC
T4281	Endoxifen	(E/Z)-N-desmethyl-4-hydroxy Tamoxifen,(E/Z)-Endoxifen	Estrogen Receptor/ERR , Aromatase , Estrogen/progestogen Receptor , Parasite , Drug Metabolite
	(E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-f...
T36083	DS-7423		PI3K , mTOR
	DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2]. DS-7423 increases TP53 expression, the level of p-TP53 on Ser...		PI3K , mTOR
T9928	Ranibizumab		VEGFR
	Ranibizumab is a humanized monoclonal antibody fragment designed to target and inhibit vascular endothelial growth factor (VEGF), including VEGF110, VEGF121, and VEGF165. Ranibizumab's ability to selectively target and n...		VEGFR
T4567	Sulfaphenazole	Plisulfan,Raziosulfa,Depocid,Depotsulfonamide	P450 , Antibacterial
	Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1...		P450 , Antibacterial
T2265	Bimiralisib	5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,PQR309,PI3K-IN-2	Others , PI3K , S6 Kinase , mTOR
	Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to ...		Others , PI3K , S6 Kinase , mTOR
T9611	PF-04802367		GSK-3
	PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. It shows desirable central nervous system (CNS) properties and ...		GSK-3
T37149	Carbamazepine 10,11-epoxide		Others
	Carbamazepine 10,11-epoxide is an active metabolite of the anticonvulsant carbamazepine.1,2It is formed from carbamazepine by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C8 in microsomes prepared from HepG2 cells e...		Others
T37020	Endosidin-2	ES2,Endosidin 2
	Endosidin-2 is an exocyst inhibitor, a cell-permeable benzylidene benzoylhydrazine, that binds to the exocyst component of the 70 kDa (EXO70) subunit of the exocyst complex (Kd = 253 μM, EXO70A1).Endosidin-2 disrupts pro...
T10804	CHMFL-PI3KD-317		PI3K , PI4K
	CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC50, ...		PI3K , PI4K
T38436	JAK-2/3-IN-1
	JAK-2/3-IN-1 is a highly effective inhibitor targeting both JAK-2 and JAK-3 isoforms. It exhibits remarkable potency, with Ki values below 250 nM for both isoforms.
T26298	Ts-SA	tsSA
	ts-SA is a metalloenzyme carbonic anhydrase (CA) inhibitor. It is active against 7 out of 10 human CA isoforms.
T15657	KH-CB19		Others
	KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).		Others
T70460	HM5023507
	HM5023507, an orally active dual inhibitor of δγ isoforms in immune signaling. HM5023507 inhibited PI3Kδ and PI3Kγ isoforms with greater than 100-fold selectivity against PI3Kα and PI3Kβ in recombinant enzymatic assays a...

Compounds

3-Cyano-7-ethoxycoumarin

Synonym: hNTPDase-IN-2

Target: Serine/threonin kinase

Synonym: ZINC211117138

Target: PI3K, Bcr-Abl

BVT948

T14841

Synonym:

Target: Phosphatase, P450, Histone Methyltransferase

Zoniporide hydrochloride

T21996

Synonym: CP-597396 hydrochloride

Target: Sodium Channel

NOS-IN-1

T21700

Synonym: 2-Imino-4-methylpiperidine (acetate)

Target: NOS

Duvelisib

T1988

Synonym: INK1197,IPI-145

Target: Apoptosis, mTOR, Autophagy

Guan-fu base A hydrochloride(1394-48-5 free base)

Target: TRP/TRPV Channel

Galloflavin

T22336

Synonym:

Target: Dehydrogenase

Synonym: FGFR-moAb,FGFR2-TTC,BAY 1179470

Target: FGFR

S-(2-aminoethyl) Isothiourea (dihydrobromide)

Synonym: GG 745,Avodart,GI 198745

Target: Apoptosis, Reductase

Target: PI3K, Autophagy

Synonym: LY-320236,LY320236,UNII-A5E8C36F34

Target: Reductase

7-BFC

T117521

Synonym: 7-Benzyloxy-4-(trifluoromethyl)coumarin,Y040-0031

Synonym: Distraneurin,Chlormethiazole,5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE

Target: P450, GABA Receptor

Trometamol

T0961

Synonym: Tromethamine

Target: p38 MAPK, Autophagy

L-NMMA acetate

T15697

Synonym: Tilarginine acetate,Methylarginine acetate

Target: Dehydrogenase

Umbralisib R-enantiomer

T13140

Synonym: TGR-1202 R-enantiomer,RP5264 R-enantiomer

Target: PI3K

Samotolisib

T6883

Synonym: GTPL8918,LY3023414

Target: DNA-PK, PI3K, mTOR, Autophagy

Diclofenac

T0196

Synonym: Diclofenacum,Voltaren

Target: Apoptosis, COX

Synonym: R1503,Ro4402257

Target: p38 MAPK, Autophagy

Fimepinostat

T2078

Synonym: CUDC-907,PI3K/HDAC Inhibitor,CUDC 907

Target: Apoptosis, PI3K, HDAC

Endoxifen

T4281

Synonym: (E/Z)-N-desmethyl-4-hydroxy Tamoxifen,(E/Z)-Endoxifen

Target: Estrogen Receptor/ERR, Aromatase, Estrogen/progestogen Receptor, Parasite, Drug Metabolite

Synonym: Plisulfan,Raziosulfa,Depocid,Depotsulfonamide

Target: P450, Antibacterial

Bimiralisib

T2265

Synonym: 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,PQR309,PI3K-IN-2

Target: Others, PI3K, S6 Kinase, mTOR

Carbamazepine 10,11-epoxide

Synonym: ES2,Endosidin 2

Cat No.	Product Name	Synonyms	Targets
T5594	Cedrol		P450 , Antifungal
	Cedrol is a cedrane sesquiterpenoid and a tertiary alcohol,Cedrol inhibits the cytochrome P450 (CYP) isoforms CYP2B6 and CYP3A4 (Kis = 0.9 and 3.4 μM, respectively)		P450 , Antifungal
T5239	Cholesteryl sulfate sodium	Cholesterol 3-Sulfate Sodium Salt,Sodium Cholesteryl Sulfate	Endogenous Metabolite , PKC
	Cholesteryl sulfate sodium (Sodium Cholesteryl Sulfate) is a sterol sulfate in human plasma. Cholesteryl sulfate sodium is a component of cell membrane and has a regulatory function. Cholesteryl sulfate sodium also activ...		Endogenous Metabolite , PKC
TN2019	Orobol	3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon	BCL , Caspase , PI3K
	Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α/β/γ/K/δ. Orobol exhibit...		BCL , Caspase , PI3K
T3S0860	Gitogenin		UGT
	1. Gitogenin, tigogenin, and solasodine are novel selective inhibitors of UGT1A4, and do not inhibit the activities of major human CYP isoforms. 2. Gitogenin and (25S)-5α-furastan-3β, 22, 26-triol are the inhibitors of e...		UGT
T40611	(E)-Dehydrodiconiferyl alcohol
	(E)-Dehydrodiconiferyl alcohol is a potent dual inhibitor of hCA IX and hCA XII, effectively impeding the catalytic activity of both carbonic anhydrase isoforms. Additionally, (E)-Dehydrodiconiferyl alcohol exerts inhibi...
TCA2511	11Beta-hydroxyprogesterone		Sodium Channel
	The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro and can confer mineralocorticoid activity on corticosterone...		Sodium Channel
T35895	Ingenol 3,20-dibenzoate
	Ingenol 3,20-dibenzoate is a powerful activator of protein kinase C (PKC) isoforms. It effectively induces the translocation of nPKC-delta, -epsilon, and -theta as well as PKC-mu from the cytosolic fraction to the partic...
T79979	Methyl piperate		Monoamine Oxidase
	Methylpiperic acid, a piperine alkaloid, exhibits potent inhibitory activity on monoamine oxidase (MAO), with differing efficacy on isoforms: greater inhibition of MAO-A (IC 50 27.1 μM) compared to MAO-B (IC 50 1.6 μM), ...		Monoamine Oxidase
T80014	Guvacine hydrobromide		GABA Receptor
	Guvacine hydrobromide, an alkaloid derived from the Areca catechu nut, serves as a potent inhibitor of GABA (GABA uptakp) uptake. It effectively inhibits rat GABA transporter isoforms GAT-1, GAT-2, and GAT-3, with respec...		GABA Receptor

Natural Products

Cedrol

T5594

Synonym:

Target: P450, Antifungal

Cholesteryl sulfate sodium

T5239

Synonym: Cholesterol 3-Sulfate Sodium Salt,Sodium Cholesteryl Sulfate

Target: Endogenous Metabolite, PKC

Orobol

TN2019

Synonym: 3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon

Target: BCL, Caspase, PI3K

(E)-Dehydrodiconiferyl alcohol

T40611

Synonym:

Target:

11Beta-hydroxyprogesterone

TCA2511

Synonym:

Target: Sodium Channel

Ingenol 3,20-dibenzoate

Target: Monoamine Oxidase

Guvacine hydrobromide

T80014

Synonym:

Target: GABA Receptor

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-00349	Car b 1 isoforms 1A and 1B Protein, Carpinus betulus, Recombinant (His)	Carpinus betulus	E. coli

TMPJ-00960	TMPO Protein, Human, Recombinant (His)	Human	E. coli
	Thymopentin is a member of the LEM family. Thymopentin is expressed in many tissues, highly in the adult thymus and fetal liver. The N-terminal contains two structurally independent domains, LEM domain and LEM-like domai...
TMPJ-00865	VEGF121 Protein, Human, Recombinant (His)	Human	Human Cells
	Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PD...
TMPY-04925	CD8 beta Protein, Human, Recombinant, Biotinylated	Human	HEK293
	CD8B (CD8b molecule), also known as P37 and LEU2, contains 1 Ig-like V-type (immunoglobulin-like) domain. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-...
TMPY-01446	IL-18R beta/IL-18RAP Protein, Human, Recombinant (His)	Human	HEK293
	Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding acti...
TMPY-03102	IL-18R beta/IL-18RAP Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293
	Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding acti...
TMPJ-00651	PVR Protein, Human, Recombinant (His)	Human	Human Cells
	Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entr...
TMPY-04333	LRRC15 Protein, Human, Recombinant (hFc)	Human	HEK293
	LRRC15 (Leucine-Rich Repeat Containing 15) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. The tumor antigen 15-leucine-rich repeat-containing membrane protein (LRRC15) is a transmemb...
TMPJ-00261	TGF beta 2 Protein, Mouse/Rat, Recombinant	Mouse,Rat	Human Cells
	Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofaci...
TMPJ-01471	Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant	Human/Mouse/Rat	Human Cells
	Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purifi...
TMPY-00480	NCAM1 Protein, Human, Recombinant (His)	Human	HEK293
	NCAM1 (Neural Cell Adhesion Molecule 1, also known as CD56) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. NCAM1 is a neural adhesion protein (NCAM) that belongs to the immunoglobuli...
TMPY-03284	IL-T4 Protein, Human, Recombinant (His)	Human	HEK293
	ILT4, also known as LILRB2, is a member of the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosin...
TMPY-00357	HNT/NTM Protein, Human, Recombinant (His)	Human	HEK293
	NTM (Neurotrimin) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylph...
TMPY-04730	LAG-3 Protein, Human, Recombinant (His)	Human	HEK293
	LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfami...
TMPY-05092	LAG-3 Protein, Cynomolgus, Recombinant (74 Pro, His)	Cynomolgus	HEK293
	LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfami...
TMPJ-00154	IL-15RA Protein, Mouse, Recombinant (hFc)（Human Cells）	Mouse	Human Cells
	Mouse interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, o...
TMPY-04939	LAG-3 Protein, Human, Recombinant	Human	HEK293
	LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfami...
TMPY-04989	Galectin-9 Protein, Human, Recombinant (hFc)	Human	HEK293
	LGALS9 (Galectin 9) is a Protein Coding gene. 6 alternatively spliced human isoforms have been reported. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix ...
TMPJ-00864	VEGF165 Protein, Human, Recombinant	Human	Human Cells
	Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator...
TMPY-03024	HER3/ERBB3 Protein, Rat, Recombinant (His)	Rat	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-04956	HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-01389	HER3/ERBB3 Protein, Human, Recombinant (His)	Human	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-00246	HER3/ERBB3 Protein, Rhesus, Recombinant	Rhesus	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-00399	HER3/ERBB3 Protein, Human, Recombinant	Human	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-02477	HER3/ERBB3 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-03407	NQO1 Protein, Human, Recombinant (His)	Human	E. coli
	NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-...
TMPY-02365	HER3/ERBB3 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-02481	ACOX1 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Peroxisomal acyl-coenzyme A oxidase 1(ACOX1 or AOX) is the first enzyme of the fatty acid beta-oxidation pathway and belongs to the Acyl-CoA oxidase family. Human liver peroxisomes contain two acyl-CoA oxidases, namely, ...
TMPY-01682	LILRB3/CD85a Protein, Human, Recombinant (His)	Human	HEK293
	Leukocyte immunoglobulin-like receptor subfamily B member 3, also known as Leukocyte immunoglobulin-like receptor 3, Immunoglobulin-like transcript 5, Monocyte inhibitory receptor HL9, CD85 antigen-like family member A, ...
TMPY-05494	LILRB3/CD85a Protein, Human, Recombinant (hFc)	Human	HEK293
	Leukocyte immunoglobulin-like receptor subfamily B member 3, also known as Leukocyte immunoglobulin-like receptor 3, Immunoglobulin-like transcript 5, Monocyte inhibitory receptor HL9, CD85 antigen-like family member A, ...
TMPY-01964	CD16a Protein, Human, Recombinant (F176V, His)	Human	HEK293
	The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also ...
TMPY-02585	Acid sphingomyelinase/SMPD1 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	Sphingomyelin phosphodiesterase 1 (SMPD1) , also known as ASM ( acid sphingomyelinase ), is a member of the acid sphingomyelinase family of enzymes. Three isoforms have been identified, isoform 1 is 631 amino acids (aa) ...
TMPY-01871	IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His)	Human	HEK293
	Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA (CD125) is an interleukin 5 specific subunit of a heterodimeric cytokine recept...
TMPY-05538	CD16a Protein, Cynomolgus, Recombinant (His), Biotinylated	Cynomolgus	HEK293
	The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also ...
TMPY-02018	CD16a Protein, Rat, Recombinant (His)	Rat	HEK293
	The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also ...
TMPY-02512	Alpha-Synuclein Protein, Human, Recombinant	Human	E. coli
	Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associate...
TMPY-01076	Gp130/IL6ST Protein, Human, Recombinant (His & hFc)	Human	HEK293
	Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta, or CD130) is a transmembrane protein that is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines...
TMPY-01832	Gp130/IL6ST Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta, or CD130) is a transmembrane protein that is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines...
TMPY-04165	FGFR3 Protein, Human, Recombinant (His)	Human	HEK293
	FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ ...
TMPY-04699	GAD65 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	Glutamate decarboxylase 2, also known as glutamate decarboxylase 65 kDa isoform, 65 kDa glutamic acid decarboxylase, GAD2 and GAD65, is a member of thegroup II decarboxylase family. GAD2 is identified as a major autoanti...
TMPY-01139	PDGFRA Protein, Human, Recombinant (His)	Human	HEK293
	PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfami...
TMPY-00341	FGFR3 Protein, Human, Recombinant (alpha IIIb, His)	Human	HEK293
	FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ ...
TMPY-04976	PDGFC Protein, Mouse, Recombinant (His)	Mouse	Yeast
	PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique domain organization and expression pattern. Platelet-derived growth factor receptors (PDGFRs) are catalytic receptors that have intracellular tyr...
TMPJ-00042	TSLP Protein, Human, Recombinant	Human	E. coli
	Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The human TSLP protein comprises a 28 amino aci...
TMPY-06034	FGFR1 Protein, Human, Recombinant (beta (IIIb), His)	Human	HEK293
	FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another i...
TMPY-01011	FGFR1 Protein, Human, Recombinant (His)	Human	HEK293
	FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another i...
TMPY-01882	HE4 Protein, Human, Recombinant (His)	Human	HEK293
	WAP four-disulfide core domain protein 2, also known as Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, WFDC2 and HE4, is a secreted protein that contains two WAP ...
TMPY-01250	IL-11R alpha/IL-11RA Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, includi...
TMPY-06036	FGFR1 Protein, Human, Recombinant (alpha (IIIb), His)	Human	HEK293
	FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another i...
TMPY-05593	IL-1RAP/IL-1RAcP Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a cytokine receptor that binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane ...
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Car b 1 isoforms 1A and 1B Protein, Carpinus betulus, Recombinant (His)

TMPH-00349

Species: Carpinus betulus

Expression System: E. coli

TMPO Protein, Human, Recombinant (His)

TMPJ-00960

Species: Human

Expression System: E. coli

VEGF121 Protein, Human, Recombinant (His)

TMPJ-00865

Species: Human

Expression System: Human Cells

CD8 beta Protein, Human, Recombinant, Biotinylated

TMPY-04925

Species: Human

Expression System: HEK293

IL-18R beta/IL-18RAP Protein, Human, Recombinant (His)

TMPY-01446

Species: Human

Expression System: HEK293

IL-18R beta/IL-18RAP Protein, Rhesus, Recombinant (hFc)

TMPY-03102

Species: Rhesus

Expression System: HEK293

PVR Protein, Human, Recombinant (His)

TMPJ-00651

Species: Human

Expression System: Human Cells

LRRC15 Protein, Human, Recombinant (hFc)

TMPY-04333

Species: Human

Expression System: HEK293

TGF beta 2 Protein, Mouse/Rat, Recombinant

TMPJ-00261

Species: Mouse,Rat

Expression System: Human Cells

Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant

TMPJ-01471

Species: Human/Mouse/Rat

Expression System: Human Cells

NCAM1 Protein, Human, Recombinant (His)

TMPY-00480

Species: Human

Expression System: HEK293

IL-T4 Protein, Human, Recombinant (His)

TMPY-03284

Species: Human

Expression System: HEK293

HNT/NTM Protein, Human, Recombinant (His)

TMPY-00357

Species: Human

Expression System: HEK293

LAG-3 Protein, Human, Recombinant (His)

TMPY-04730

Species: Human

Expression System: HEK293

LAG-3 Protein, Cynomolgus, Recombinant (74 Pro, His)

TMPY-05092

Species: Cynomolgus

Expression System: HEK293

IL-15RA Protein, Mouse, Recombinant (hFc)（Human Cells）

TMPJ-00154

Species: Mouse

Expression System: Human Cells

LAG-3 Protein, Human, Recombinant

TMPY-04939

Species: Human

Expression System: HEK293

Galectin-9 Protein, Human, Recombinant (hFc)

TMPY-04989

Species: Human

Expression System: HEK293

VEGF165 Protein, Human, Recombinant

TMPJ-00864

Species: Human

Expression System: Human Cells

HER3/ERBB3 Protein, Rat, Recombinant (His)

TMPY-03024

Species: Rat

Expression System: HEK293

HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated

TMPY-04956

Species: Human

Expression System: HEK293

HER3/ERBB3 Protein, Human, Recombinant (His)

TMPY-01389

Species: Human

Expression System: HEK293

HER3/ERBB3 Protein, Rhesus, Recombinant

TMPY-00246

Species: Rhesus

Expression System: HEK293

HER3/ERBB3 Protein, Human, Recombinant

TMPY-00399

Species: Human

Expression System: HEK293

HER3/ERBB3 Protein, Rhesus, Recombinant (His)

TMPY-02477

Species: Rhesus

Expression System: HEK293

NQO1 Protein, Human, Recombinant (His)

TMPY-03407

Species: Human

Expression System: E. coli

HER3/ERBB3 Protein, Mouse, Recombinant (His)

TMPY-02365

Species: Mouse

Expression System: HEK293

ACOX1 Protein, Human, Recombinant (His)

TMPY-02481

Species: Human

Expression System: Baculovirus-Insect Cells

LILRB3/CD85a Protein, Human, Recombinant (His)

TMPY-01682

Species: Human

Expression System: HEK293

LILRB3/CD85a Protein, Human, Recombinant (hFc)

TMPY-05494

Species: Human

Expression System: HEK293

CD16a Protein, Human, Recombinant (F176V, His)

TMPY-01964

Species: Human

Expression System: HEK293

Acid sphingomyelinase/SMPD1 Protein, Mouse, Recombinant (His)

TMPY-02585

Species: Mouse

Expression System: Baculovirus-Insect Cells

IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His)

TMPY-01871

Species: Human

Expression System: HEK293

CD16a Protein, Cynomolgus, Recombinant (His), Biotinylated

TMPY-05538

Species: Cynomolgus

Expression System: HEK293

CD16a Protein, Rat, Recombinant (His)

TMPY-02018

Species: Rat

Expression System: HEK293

Alpha-Synuclein Protein, Human, Recombinant

TMPY-02512

Species: Human

Expression System: E. coli

gp130/IL6ST Protein, Human, Recombinant (His & hFc)

TMPY-01076

Species: Human

Expression System: HEK293

gp130/IL6ST Protein, Mouse, Recombinant (His)

TMPY-01832

Species: Mouse

Expression System: HEK293

FGFR3 Protein, Human, Recombinant (His)

TMPY-04165

Species: Human

Expression System: HEK293

GAD65 Protein, Human, Recombinant (GST)

TMPY-04699

Species: Human

Expression System: Baculovirus-Insect Cells

PDGFRA Protein, Human, Recombinant (His)

TMPY-01139

Species: Human

Expression System: HEK293

FGFR3 Protein, Human, Recombinant (alpha IIIb, His)

TMPY-00341

Species: Human

Expression System: HEK293

PDGFC Protein, Mouse, Recombinant (His)

TMPY-04976

Species: Mouse

Expression System: Yeast

TSLP Protein, Human, Recombinant

TMPJ-00042

Species: Human

Expression System: E. coli

FGFR1 Protein, Human, Recombinant (beta (IIIb), His)

TMPY-06034

Species: Human

Expression System: HEK293

FGFR1 Protein, Human, Recombinant (His)

TMPY-01011

Species: Human

Expression System: HEK293

HE4 Protein, Human, Recombinant (His)

TMPY-01882

Species: Human

Expression System: HEK293

IL-11R alpha/IL-11RA Protein, Mouse, Recombinant (His)

TMPY-01250

Species: Mouse

Expression System: HEK293

FGFR1 Protein, Human, Recombinant (alpha (IIIb), His)

TMPY-06036

Species: Human

Expression System: HEK293

IL-1RAP/IL-1RAcP Protein, Human, Recombinant (His & Avi), Biotinylated

TMPY-05593

Species: Human

Expression System: HEK293

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Cat No.	Product Name
L4100	TGF-beta/Smad Compound Library	185 compounds
	A unique collection of 185 TGF-beta/Smad signaling targeted compounds for high throughput and high content screening;
L7400	Sodium Channel Blocker Library	128 compounds
	A unique collection of 128 sodium channel blockers and agonists for high throughput and high content screening;
L2550	Glutamine Metabolism Compound Library	580 compounds
	A unique collection of 580 glutamine metabolism related compounds can be used for high throughput screening (HTS) and high content screening (HCS), and also is an effective tool for research in glutamine metabolism and ...

Libraries

TGF-beta/Smad Compound Library

L4100

Compounds: 185

Sodium Channel Blocker Library

L7400

Compounds: 128

Glutamine Metabolism Compound Library

L2550

Compounds: 580