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Description | PI5P4Ks-IN-2 is an inhibitor of the phosphatidylinositol 5-phosphate 4-kinase PI5P4Kγ. Targeting the PI5P4K isoforms, PI5P4Ks-IN-2 inhibited PI5P4Kα, PI5P4Kβ, PI5P4Kγ, and PI5P4Kγ+, with IC50 values of <4.3, <4.6, 6.2, and 0.32, respectively. |
Targets&IC50 | PI5P4Kα:<4.3(pIC50), PI5P4Kβ:>30 μM(Ki), PI5P4Kβ:<4.6(pIC50), PI5P4Kγ+:0.32(pIC50), PI5P4Kγ (WT):68 nM(Ki), PI5P4Kγ:6.2(pIC50) |
In vitro | PI5P4Ks-IN-2 (10 μM) showed selectivity towards a group of 140 protein kinases and 15 lipid kinases, binding to PI5P4Kγ-WT (Ki=68 nM) or PI5P4Kβ (Ki >30,000 nM).[1] |
In vivo | PI5P4Ks-IN-2 (10 μM) showed selectivity towards a group of 140 protein kinases and 15 lipid kinases, binding to PI5P4Kγ-WT (Ki=68 nM) or PI5P4Kβ (Ki >30,000 nM).[1] |
Molecular Weight | 357.45 |
Formula | C22H23N5 |
Cas No. | 2766854-03-7 |
Storage | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 27.5 mg/mL (72.08 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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