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PI5P4Ks-IN-2

PI5P4Ks-IN-2
PI5P4Ks-IN-2 is an inhibitor of the phosphatidylinositol 5-phosphate 4-kinase PI5P4Kγ. Targeting the PI5P4K isoforms, PI5P4Ks-IN-2 inhibited PI5P4Kα, PI5P4Kβ, PI5P4Kγ, and PI5P4Kγ+, with IC50 values of <4.3, <4.6, 6.2, and 0.32, respectively.
Catalog No. T72032Cas No. 2766854-03-7
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Purity:99.21%
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PI5P4Ks-IN-2

Catalog No. T72032Cas No. 2766854-03-7

PI5P4Ks-IN-2 is an inhibitor of the phosphatidylinositol 5-phosphate 4-kinase PI5P4Kγ. Targeting the PI5P4K isoforms, PI5P4Ks-IN-2 inhibited PI5P4Kα, PI5P4Kβ, PI5P4Kγ, and PI5P4Kγ+, with IC50 values of <4.3, <4.6, 6.2, and 0.32, respectively.
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Product Introduction

Bioactivity
Description
PI5P4Ks-IN-2 is an inhibitor of the phosphatidylinositol 5-phosphate 4-kinase PI5P4Kγ. Targeting the PI5P4K isoforms, PI5P4Ks-IN-2 inhibited PI5P4Kα, PI5P4Kβ, PI5P4Kγ, and PI5P4Kγ+, with IC50 values of <4.3, <4.6, 6.2, and 0.32, respectively.
Targets&IC50
PI5P4Kα:<4.3(pIC50), PI5P4Kβ:>30 μM(Ki), PI5P4Kβ:<4.6(pIC50), PI5P4Kγ+:0.32(pIC50), PI5P4Kγ (WT):68 nM(Ki), PI5P4Kγ:6.2(pIC50)
In vitro
PI5P4Ks-IN-2 (10 μM) showed selectivity towards a group of 140 protein kinases and 15 lipid kinases, binding to PI5P4Kγ-WT (Ki=68 nM) or PI5P4Kβ (Ki >30,000 nM).[1]
In vivo
PI5P4Ks-IN-2 (10 μM) showed selectivity towards a group of 140 protein kinases and 15 lipid kinases, binding to PI5P4Kγ-WT (Ki=68 nM) or PI5P4Kβ (Ki >30,000 nM).[1]
Chemical Properties
Molecular Weight357.45
FormulaC22H23N5
Cas No.2766854-03-7
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 27.5 mg/mL (72.08 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7976 mL13.9880 mL27.9759 mL139.8797 mL
5 mM0.5595 mL2.7976 mL5.5952 mL27.9759 mL
10 mM0.2798 mL1.3988 mL2.7976 mL13.9880 mL
20 mM0.1399 mL0.6994 mL1.3988 mL6.9940 mL
50 mM0.0560 mL0.2798 mL0.5595 mL2.7976 mL

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