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PI5P4Ks-IN-2
Catalog No. T72032Cas No. 2766854-03-7
PI5P4Ks-IN-2 is an inhibitor of the phosphatidylinositol 5-phosphate 4-kinase PI5P4Kγ. Targeting the PI5P4K isoforms, PI5P4Ks-IN-2 inhibited PI5P4Kα, PI5P4Kβ, PI5P4Kγ, and PI5P4Kγ+, with IC50 values of <4.3, <4.6, 6.2, and 0.32, respectively.
PI5P4Ks-IN-2
Catalog No. T72032Cas No. 2766854-03-7
PI5P4Ks-IN-2 is an inhibitor of the phosphatidylinositol 5-phosphate 4-kinase PI5P4Kγ. Targeting the PI5P4K isoforms, PI5P4Ks-IN-2 inhibited PI5P4Kα, PI5P4Kβ, PI5P4Kγ, and PI5P4Kγ+, with IC50 values of <4.3, <4.6, 6.2, and 0.32, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $163 | In Stock | |
| 5 mg | $355 | In Stock | |
| 10 mg | $529 | In Stock | |
| 25 mg | $893 | In Stock | |
| 50 mg | $1,170 | In Stock | |
| 100 mg | $1,530 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $389 | In Stock |
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Purity:99.21%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PI5P4Ks-IN-2 is an inhibitor of the phosphatidylinositol 5-phosphate 4-kinase PI5P4Kγ. Targeting the PI5P4K isoforms, PI5P4Ks-IN-2 inhibited PI5P4Kα, PI5P4Kβ, PI5P4Kγ, and PI5P4Kγ+, with IC50 values of <4.3, <4.6, 6.2, and 0.32, respectively. |
| Targets&IC50 | PI5P4Kγ+:0.32(pIC50), PI5P4Kγ (WT):68 nM(Ki), PI5P4Kα:<4.3(pIC50), PI5P4Kγ:6.2(pIC50), PI5P4Kβ:＞30 μM(Ki), PI5P4Kβ:<4.6(pIC50) |
| In vitro | PI5P4Ks-IN-2 (10 μM) showed selectivity towards a group of 140 protein kinases and 15 lipid kinases, binding to PI5P4Kγ-WT (Ki=68 nM) or PI5P4Kβ (Ki >30,000 nM).[1] |
| In vivo | PI5P4Ks-IN-2 (10 μM) showed selectivity towards a group of 140 protein kinases and 15 lipid kinases, binding to PI5P4Kγ-WT (Ki=68 nM) or PI5P4Kβ (Ki >30,000 nM).[1] |
| Molecular Weight | 357.45 |
| Formula | C22H23N5 |
| Cas No. | 2766854-03-7 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 27.5 mg/mL (72.08 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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