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L-NMMA acetate

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COA HNMR

L-NMMA acetate

Catalog No. T15697Cas No. 53308-83-1

L-NMMA acetate (Tilarginine acetate) is an inhibitor of nitric oxide synthase of all NOS isoforms (i.e. NOS1, NOS2, and NOS3). The Ki values are 0.18, 0.4, and 6 µM for nNOS, eNOS, and iNOS, respectively.

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Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$48	In Stock
5 mg	$76	In Stock
10 mg	$109	In Stock
25 mg	$183	In Stock
50 mg	$272	In Stock
100 mg	$397	In Stock

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Product Introduction

Bioactivity

Description	L-NMMA acetate (Tilarginine acetate) is an inhibitor of nitric oxide synthase of all NOS isoforms (i.e. NOS1, NOS2, and NOS3). The Ki values are 0.18, 0.4, and 6 µM for nNOS, eNOS, and iNOS, respectively.
In vitro	L-NMMA selectively inhibits vasodilator responses to endothelium-dependent ACh without affecting responses to endothelium-independent NP and does not alter isoprenaline-induced relaxation. Its inhibitory action remains unaffected by D-arginine but is countered by L-arginine (L-Arg). L-NMMA initiates a concentration-dependent decrease in vasodilation (2Hz) starting at 100 μM, achieving maximum inhibition around 35% at 1 mM. It reduces arteriolar diameter and increases arteriolar tone in a dose-dependent manner with an immediate onset of action. Moreover, L-NMMA significantly enhances NE-induced vasoconstriction.
Alias	Tilarginine acetate, Methylarginine acetate

Chemical Properties

Molecular Weight	248.28
Formula	C9H20N4O4
Cas No.	53308-83-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (201.39 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	4.0277 mL	20.1386 mL	40.2771 mL	201.3855 mL
5 mM	0.8055 mL	4.0277 mL	8.0554 mL	40.2771 mL
10 mM	0.4028 mL	2.0139 mL	4.0277 mL	20.1386 mL
20 mM	0.2014 mL	1.0069 mL	2.0139 mL	10.0693 mL
50 mM	0.0806 mL	0.4028 mL	0.8055 mL	4.0277 mL
100 mM	0.0403 mL	0.2014 mL	0.4028 mL	2.0139 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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