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L-NMMA acetate

L-NMMA acetate
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L-NMMA acetate

Catalog No. T15697Cas No. 53308-83-1
L-NMMA acetate (Tilarginine acetate) is an inhibitor of nitric oxide synthase of all NOS isoforms (i.e. NOS1, NOS2, and NOS3). The Ki values are 0.18, 0.4, and 6 µM for nNOS, eNOS, and iNOS, respectively.
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Pack SizePriceAvailabilityQuantity
1 mg$34In Stock
2 mg$48In Stock
5 mg$76In Stock
10 mg$109In Stock
25 mg$183In Stock
50 mg$272In Stock
100 mg$397In Stock
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Related Compound Libraries of "L-NMMA acetate"

Product Introduction

Bioactivity
Description
L-NMMA acetate (Tilarginine acetate) is an inhibitor of nitric oxide synthase of all NOS isoforms (i.e. NOS1, NOS2, and NOS3). The Ki values are 0.18, 0.4, and 6 µM for nNOS, eNOS, and iNOS, respectively.
In vitro
L-NMMA selectively inhibits vasodilator responses to endothelium-dependent ACh without affecting responses to endothelium-independent NP and does not alter isoprenaline-induced relaxation. Its inhibitory action remains unaffected by D-arginine but is countered by L-arginine (L-Arg). L-NMMA initiates a concentration-dependent decrease in vasodilation (2Hz) starting at 100 μM, achieving maximum inhibition around 35% at 1 mM. It reduces arteriolar diameter and increases arteriolar tone in a dose-dependent manner with an immediate onset of action. Moreover, L-NMMA significantly enhances NE-induced vasoconstriction.
AliasTilarginine acetate, Methylarginine acetate
Chemical Properties
Molecular Weight248.28
FormulaC9H20N4O4
Cas No.53308-83-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 50 mg/mL (201.39 mM)
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM4.0277 mL20.1386 mL40.2771 mL201.3855 mL
5 mM0.8055 mL4.0277 mL8.0554 mL40.2771 mL
10 mM0.4028 mL2.0139 mL4.0277 mL20.1386 mL
20 mM0.2014 mL1.0069 mL2.0139 mL10.0693 mL
50 mM0.0806 mL0.4028 mL0.8055 mL4.0277 mL
100 mM0.0403 mL0.2014 mL0.4028 mL2.0139 mL

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