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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $191 | In Stock | |
2 mg | $287 | In Stock |
Description | Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α/β/γ/K/δ. Orobol exhibits anti-skin-aging and anti-obesity effects. |
In vitro | Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK with IC50s of 1.24-4.45 μM. Orobol (5-20 μM) effectively suppresses MDI (isobutylmethylxanthine, dexamethasone, and insulin (MDI))-induced phosphorylation of 4E-BP1. Orobol binds to CK1ε in an ATP-competitive manner[3]. |
In vivo | In C57BL/6J mice, Orobol (10 mg/kg; intragastrically) attenuates high-fat diet-induced weight gain (17.3%) and lipid accumulation without affecting food intake[3]. |
Alias | 3'-Hydroxygenistein, 3’,4’,5,7-tetrahydroxy-isoflavon |
Molecular Weight | 286.24 |
Formula | C15H10O6 |
Cas No. | 480-23-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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