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Dalcotidine

Catalog No. T31195Cas No. 120958-90-9
Alias KU-1257, KU 1257

Dalcotidine (KU 1257) is a novel histamine H2 receptor antagonist with histamine H9 receptor antagonistic activity and antisecretory effects.The Ki value for binding to guinea pig cerebral cortex was 0.040 The KB value for antagonism of histamine-induced positive chronotropic responses in the right atrium of isolate guinea pigs was 0.041.Dalcotidine improves the quality of ulcer healing, and may contribute to a reduction in ulcer recurrence and relapse rates.

Dalcotidine

Dalcotidine

Purity: 98.34%
Catalog No. T31195Alias KU-1257, KU 1257Cas No. 120958-90-9
Dalcotidine (KU 1257) is a novel histamine H2 receptor antagonist with histamine H9 receptor antagonistic activity and antisecretory effects.The Ki value for binding to guinea pig cerebral cortex was 0.040 The KB value for antagonism of histamine-induced positive chronotropic responses in the right atrium of isolate guinea pigs was 0.041.Dalcotidine improves the quality of ulcer healing, and may contribute to a reduction in ulcer recurrence and relapse rates.
Pack SizePriceAvailabilityQuantity
1 mg$143In Stock
5 mg$360In Stock
10 mg$530In Stock
25 mg$859In Stock
50 mg$1,180In Stock
100 mg$1,590In Stock
500 mg$3,190In Stock
1 mL x 10 mM (in DMSO)$358In Stock
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Purity:98.34%
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Product Introduction

Bioactivity
Description
Dalcotidine (KU 1257) is a novel histamine H2 receptor antagonist with histamine H9 receptor antagonistic activity and antisecretory effects.The Ki value for binding to guinea pig cerebral cortex was 0.040 The KB value for antagonism of histamine-induced positive chronotropic responses in the right atrium of isolate guinea pigs was 0.041.Dalcotidine improves the quality of ulcer healing, and may contribute to a reduction in ulcer recurrence and relapse rates.
Targets&IC50
H2 receptor:0.04 mumol/l
In vivo
Dalcotidine (10-50 mg/kg x 2/day; oral; rats)markedly promoted the well-balanced healing of gastric ulcers, as evidenced by the reduction of ulcers, regeneration of mucosa and proliferation of connective tissue. Dalcotidine caused an increase in gastric mucus secretion in the regenerated mucosa around the gastric ulcers. Dalcotidine is characterized by a potent promoting action on the healing of chronic ulcers, suggesting that the increase in gastric mucus secretion might be associated with the antiulcer actions of Dalcotidine in part.[2]
AliasKU-1257, KU 1257
Chemical Properties
Molecular Weight319.44
FormulaC18H29N3O2
Cas No.120958-90-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 3.6 mg/mL (11.27 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1305 mL15.6524 mL31.3048 mL156.5239 mL
5 mM0.6261 mL3.1305 mL6.2610 mL31.3048 mL
10 mM0.3130 mL1.5652 mL3.1305 mL15.6524 mL

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