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Dihydrocapsaicin

Catalog No. T2163   CAS 19408-84-5
Synonyms: CCRIS1589, 6,7-Dihydrocapsaicin, 8-Methyl-N-vanillylnonanamide

Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an irritant. Capsaicin is found in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in order to obtain pure dihydrocapsaicin. Dihydrocapsaicin represents about 10% of the compound present in commercial preparations purporting to be pure capsaicin, but it has about the same pungency as capsaicin. VR1 (vanilloid receptor 1) is a heat activated calcium ion channel which functions as a part of the normal nociceptive pain pathway. Capsaicin elicits a sensation of burning pain by activation of VR1 on small, non-myelinated polymodal C-type nociceptive nerve fibers. The potency of dihydrocapsaicin at VR1 appears equivalent to capsaicin. Antioxidant. Reduces oxidation of serum lipids. Mutagenic. Dihydrocapsaicin is an activator of VR1.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Dihydrocapsaicin Chemical Structure
Dihydrocapsaicin, CAS 19408-84-5
Pack Size Availability Price/USD Quantity
10 mg In stock $ 48.00
25 mg In stock $ 97.00
50 mg In stock $ 157.00
100 mg In stock $ 237.00
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Purity: 99.8%
Purity: 99.61%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an irritant. Capsaicin is found in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in order to obtain pure dihydrocapsaicin. Dihydrocapsaicin represents about 10% of the compound present in commercial preparations purporting to be pure capsaicin, but it has about the same pungency as capsaicin. VR1 (vanilloid receptor 1) is a heat activated calcium ion channel which functions as a part of the normal nociceptive pain pathway. Capsaicin elicits a sensation of burning pain by activation of VR1 on small, non-myelinated polymodal C-type nociceptive nerve fibers. The potency of dihydrocapsaicin at VR1 appears equivalent to capsaicin. Antioxidant. Reduces oxidation of serum lipids. Mutagenic. Dihydrocapsaicin is an activator of VR1.
Source
Synonyms CCRIS1589, 6,7-Dihydrocapsaicin, 8-Methyl-N-vanillylnonanamide
Molecular Weight 307.43
Formula C18H29NO3
CAS No. 19408-84-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 32.5 mM

TargetMolReferences and Literature

1. Lawson T, et al. The mutagenicity of capsaicin and dihydrocapsaicin in V79 cells. Cancer Lett. 1989 Nov 30;48(2):109-13. 2. Ramírez-Romero R, et al. Dihydrocapsaicin treatment depletes peptidergic nerve fibers of substance P and alters mast cell density in the respiratory tract of neonatal sheep. Regul Pept. 2 Jul 28;91(1-3):97-16.

TargetMolCitations

1. Zhang B, Zhao J, Wang Z, et al. Identification of Multi-Target Anti-AD Chemical Constituents From Traditional Chinese Medicine Formulae by Integrating Virtual Screening and In Vitro Validation. Frontiers in Pharmacology. 2021：1781

Related compound libraries

This product is contained In the following compound libraries：
Membrane Protein-targeted Compound Library FDA-Approved & Pharmacopeia Drug Library Bioactive Lipid Compound Library Selected Plant-Sourced Compound Library Oxidation-Reduction Compound Library Autophagy Compound Library Human Endogenous Metabolite Compound Library Plus Chinese Pharmacopoeia Natural Product Library NO PAINS Compound Library Bioactive Compound Library

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Keywords

Dihydrocapsaicin 19408-84-5 Membrane transporter/Ion channel Others TRP/TRPV Channel middle cerebral artery occlusion Phosphoinositide 3-kinase hypothermic PI3K Inhibitor Transient receptor potential channels ROS Reactive Oxygen Species CCRIS1589 Bcl-2 Family Caspase 6,7-Dihydrocapsaicin inhibit Ischemia-reperfusion PKB neuroprotection MCAO Apoptosis CCRIS 1589 TRP Channel 8-Methyl-N-vanillylnonanamide CCRIS-1589 Protein kinase B Akt inhibitor

 

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