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Dihydrocoumarin

Catalog No. T2S0300 CAS 119-84-6

Synonyms: Chroman-2-one, Hydrocoumarin, melilotin, 2-chromanone, 3,4-dihydrocoumarin

Dihydrocoumarin (melilotin) is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.

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Dihydrocoumarin, CAS 119-84-6

Pack Size	Availability	Price/USD	Quantity
10 g	In stock	$ 29.00
1 mL * 10 mM (in DMSO)	In stock	$ 29.00

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Purity: 99.19%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Dihydrocoumarin (melilotin) is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively.
Targets&IC50	SIRT2 (human):295 μM, SIRT1 (human):208 μM
Source	Natural Products > Fabaceae > Glycine

Synonyms	Chroman-2-one, Hydrocoumarin, melilotin, 2-chromanone, 3,4-dihydrocoumarin
Molecular Weight	148.16
Formula	C9H8O2
CAS No.	119-84-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11 mg/mL (74.24 mM)

References and Literature

1. Podyma W, Baczek K, Angielczyk M, et al. The influence of shading on the yield and quality of southern sweet-grass (Hierochloë australis (Schrad.) Roem. & Schult.) raw material.[J]. Herba Polonica, 2010, 56(4):14-19.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Tobacco Monomer Library Traditional Chinese Medicine Monomer Library NO PAINS Compound Library Natural Product Library Anti-Aging Compound Library Epigenetics Compound Library Natural Product Library for HTS Anti-Diabetic Compound Library ReFRAME Related Library

Related Products

Related compounds with same targets

Fisetin WAY-323061 SIRT1 activator 1 Z26395438 Sirt1/2-IN-3 SRT 1460 Thiomyristoyl Ophiopogonin D'

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Dihydrocoumarin 119-84-6 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin Chroman-2-one inhibit Hydrocoumarin Inhibitor melilotin 2-chromanone 3,4-dihydrocoumarin inhibitor

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