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Product Introduction

Bioactivity

Description	Dimesna (BNP-7787) is a synthetic derivative of dithio-ethane sulfonate with uroprotective properties.
In vitro	Dimesna modulated paclitaxel-induced MTP hyperpolymerization, and mesna, an in vivo metabolite of Dimesna, prevented cisplatin-induced MTP inactivation. The renal organic anion transporter proteins OAT1 (KM=636 μM), OAT3 (KM=390 μM) and OAT4 (KM=590 μM) were able to specifically bind Dimesna.
In vivo	Dimesna modulated paclitaxel-induced MTP hyperpolymerization, and mesna, an in vivo metabolite of Dimesna, prevented cisplatin-induced MTP inactivation. The renal organic anion transporter proteins OAT1 (KM=636 μM), OAT3 (KM=390 μM) and OAT4 (KM=590 μM) were able to specifically bind Dimesna.
Alias	BNP-7787

Chemical Properties

Molecular Weight	326.34
Formula	C₄H₈Na₂O₆S₄
Cas No.	16208-51-8
Smiles	[O-]S(=O)(=O)CCSSCCS(=O)(=O)[O-].[Na+].[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 13 mg/mL (39.84 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0643 mL	15.3214 mL	30.6429 mL	153.2144 mL
5 mM	0.6129 mL	3.0643 mL	6.1286 mL	30.6429 mL
10 mM	0.3064 mL	1.5321 mL	3.0643 mL	15.3214 mL
20 mM	0.1532 mL	0.7661 mL	1.5321 mL	7.6607 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

organic anion transporterInhibitorinhibitDimesnaBNP7787BNP 7787