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Duloxetine

Duloxetine
Duloxetine is an inhibitor of serotonin-norepinephrine reuptake(Ki of 4.6 nM),with treatment of major depressive disorder and generalized anxiety disorder.
Catalog No. T7061Cas No. 116539-59-4
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Purity:99.75%
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Duloxetine

Catalog No. T7061Cas No. 116539-59-4
Duloxetine is an inhibitor of serotonin-norepinephrine reuptake(Ki of 4.6 nM),with treatment of major depressive disorder and generalized anxiety disorder.
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Pack SizePriceAvailabilityQuantity
5 mg$40In Stock
10 mg$57In Stock
25 mg$94In Stock
50 mg$139In Stock
100 mg$198In Stock
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Product Introduction

Bioactivity
Description
Duloxetine is an inhibitor of serotonin-norepinephrine reuptake(Ki of 4.6 nM),with treatment of major depressive disorder and generalized anxiety disorder.
Targets&IC50
5-HT-Norepinephrine reuptake:4.6 nM(ki)
In vitro
IC50 of duloxetine for the resting and inactivated wild-type hNav1.7 Na+ channel were 22.1+/-0.4 and 1.79+/-0.10 microM, respectively (mean+/-SE, n=5).?The IC50 for the open Na+ channel was 0.25+/-0.02 microM (n=5), as determined by the block of persistent late Nav1.7 Na+ currents.?Similar open-channel block by duloxetine was found in the muscle Nav1.4 isoform (IC50=0.51+/-0.05 microM;?n=5).?Block by duloxetine appeared via the conserved local anesthetic receptor as determined by site-directed mutagenesis.?Finally, duloxetine elicited strong use-dependent block of neuronal transient Nav1.7 Na+ currents during repetitive stimulations[1].
Cell Research
Used the whole cell, patch clamp technique to test whether duloxetine interacts with the neuronal Nav1.7 Na+ channel as a potential target.?Resting and inactivated Nav1.7 Na+ channel block by duloxetine were measured by conventional pulse protocols in transfected human embryonic kidney cells.?The open-channel block was determined directly using inactivation-deficient mutant Nav1.7 Na+ channels[1].
Chemical Properties
Molecular Weight297.41
FormulaC18H19NOS
Cas No.116539-59-4
Storage & Solubility Information
Storagestore at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (134.49 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3624 mL16.8118 mL33.6236 mL168.1181 mL
5 mM0.6725 mL3.3624 mL6.7247 mL33.6236 mL
10 mM0.3362 mL1.6812 mL3.3624 mL16.8118 mL
20 mM0.1681 mL0.8406 mL1.6812 mL8.4059 mL
50 mM0.0672 mL0.3362 mL0.6725 mL3.3624 mL
100 mM0.0336 mL0.1681 mL0.3362 mL1.6812 mL

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