store at low temperature,store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Duloxetine is an inhibitor of serotonin-norepinephrine reuptake(Ki of 4.6 nM),with treatment of major depressive disorder and generalized anxiety disorder.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 40.00 | |
10 mg | In stock | $ 57.00 | |
25 mg | In stock | $ 94.00 | |
50 mg | In stock | $ 139.00 | |
100 mg | In stock | $ 198.00 |
Description | Duloxetine is an inhibitor of serotonin-norepinephrine reuptake(Ki of 4.6 nM),with treatment of major depressive disorder and generalized anxiety disorder. |
Targets&IC50 | 5-HT-Norepinephrine reuptake:4.6 nM(ki) |
In vitro | IC50 of duloxetine for the resting and inactivated wild-type hNav1.7 Na+ channel were 22.1+/-0.4 and 1.79+/-0.10 microM, respectively (mean+/-SE, n=5).?The IC50 for the open Na+ channel was 0.25+/-0.02 microM (n=5), as determined by the block of persistent late Nav1.7 Na+ currents.?Similar open-channel block by duloxetine was found in the muscle Nav1.4 isoform (IC50=0.51+/-0.05 microM;?n=5).?Block by duloxetine appeared via the conserved local anesthetic receptor as determined by site-directed mutagenesis.?Finally, duloxetine elicited strong use-dependent block of neuronal transient Nav1.7 Na+ currents during repetitive stimulations[1]. |
Cell Research | Used the whole cell, patch clamp technique to test whether duloxetine interacts with the neuronal Nav1.7 Na+ channel as a potential target.?Resting and inactivated Nav1.7 Na+ channel block by duloxetine were measured by conventional pulse protocols in transfected human embryonic kidney cells.?The open-channel block was determined directly using inactivation-deficient mutant Nav1.7 Na+ channels[1]. |
Molecular Weight | 297.41 |
Formula | C18H19NOS |
CAS No. | 116539-59-4 |
store at low temperature,store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 15mg/mL(50.4 mM)
You can also refer to dose conversion for different animals. More
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