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EGFR/ErbB-2/ErbB-4 inhibitor-2

Catalog No. T21954 CAS 179248-61-4

Synonyms: EGFR/ErbB2 Inhibitor

EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)

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EGFR/ErbB-2/ErbB-4 inhibitor-2 Chemical Structure

EGFR/ErbB-2/ErbB-4 inhibitor-2, CAS 179248-61-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 133.00
5 mg	In stock	$ 289.00
10 mg	In stock	$ 453.00
25 mg	In stock	$ 748.00
50 mg	In stock	$ 1,050.00
100 mg	In stock	$ 1,420.00
500 mg	In stock	$ 2,830.00
1 mL * 10 mM (in DMSO)	In stock	$ 336.00

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Purity: 98.1%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)
Targets&IC50	EGFR:20 nM , c-ErbB2:79 nM

Synonyms	EGFR/ErbB2 Inhibitor
Molecular Weight	387.43
Formula	C23H21N3O3
CAS No.	179248-61-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (141.96 mM)

References and Literature

1. Cockerill S , Stubberfield C , Stables J , et al. Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2.[J]. Bioorganic & Medicinal Chemistry Letters, 2010, 32( 11):no-no.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Anti-Lung Cancer Compound Library Anti-Liver Cancer Compound Library Anti-Prostate Cancer Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Anti-Breast Cancer Compound Library Anti-Ovarian Cancer Compound Library

Related Products

Related compounds with same targets

(S)-Afatinib PAT-505 PROTAC EGFR degrader 8 Olafertinib EGFR-IN-81 Oritinib AZ-5104 Sunvozertinib

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

EGFR/ErbB-2/ErbB-4 inhibitor-2 179248-61-4 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR EGFR/ErbB2/ErbB4 inhibitor2 HER1 Inhibitor inhibit ErbB2 HN5 Epidermal growth factor receptor EGFR/ErbB 2/ErbB 4 inhibitor 2 ErbB4 EGFR/ErbB2 Inhibitor ErbB-1 inhibitor

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