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Evatanepag

Catalog No. T15259 CAS 223488-57-1

Synonyms: CP-533536 free acid

Evatanepag is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.CP-533536 demonstrated the ability to heal fractures when administered locally as a single dose in rat models of fracture healing.

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Evatanepag, CAS 223488-57-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Evatanepag is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.CP-533536 demonstrated the ability to heal fractures when administered locally as a single dose in rat models of fracture healing.
In vitro	CP-533536 is a potent and selective EP2agonist. CP-533536 shows the ability to heal fractures when administered locally as a single dose in rat models of fracture healing s excellent in vitro potency and it also displays against EP2 and selectivity against a broad panel of other targets.

Synonyms	CP-533536 free acid
Molecular Weight	468.57
Formula	C25H28N2O5S
CAS No.	223488-57-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 32 mg/mL (68.29 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Cameron KO, et al. Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation. Bioorg Med Chem Lett. 2009 Apr 1;19(7):2075-8.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Evatanepag 223488-57-1 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor HDM asthma CP533536 mast cell CP-533536 CP-533536 free acid CP 533536 bone Inhibitor Fracture healing allergy inflammation inhibit inhibitor

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