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Fingolimod

Catalog No. T7939 CAS 162359-55-9

Synonyms: FTY-720A, FTY-720

Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Fingolimod, CAS 162359-55-9

Pack Size	Availability	Price/USD
100 mg	In stock	$ 50.00
500 mg	In stock	$ 126.00
1 g	In stock	$ 158.00
1 mL * 10 mM (in DMSO)	In stock	$ 53.00

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Purity: 99.76%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
Targets&IC50	S1P1:0.033 nM
In vitro	Fingolimod has been reported to reduce LPA synthesis via inhibition of the lysophospholipase autotaxin.?Fingolimod treatment correlates with a significant elevation of axonal cAMP, a crucial factor for axonal outgrowth.?Additionally, Fingolimod significantly reduces LPA levels in the injured nerve.?PF-8380 treatment correlates with improved myelin thickness[1]
Cell Research	Sciatic nerve crush was performed in wildtype C57BL/6, in immunodeficient Rag1 (-/-) and Foxn1 (-/-) mice.?Analyses were based on walking track analysis and electrophysiology, histology, and cAMP formation.?Quantification of different LPA species was performed by liquid chromatography coupled to tandem mass spectrometry.?Furthermore, functional consequences of autotaxin inhibition by the specific inhibitor PF-8380 and the impact of fingolimod on early cytokine release in the injured sciatic nerve were investigated[1].

Synonyms	FTY-720A, FTY-720
Molecular Weight	307.47
Formula	C19H33NO2
CAS No.	162359-55-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Methanol: 30 mg/mL (97.57 mM), Sonification is recommended.

Ethanol: 7.69 mg/mL (25.01 mM), Sonification is recommended.

DMSO: 66.67 mg/mL (216.83 mM), Sonification is recommended.

References and Literature

1. Szepanowski, Fabian, Derksen, Angelika, Steiner, Irina,et al. Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling[J]. Journal of Neuroinflammation, 13(1):143. 2. Amelioration of colitis through blocking lymphocytes entry to Peyer's patches by sphingosine‐1‐phosphate lyase inhibitor[J]. Journal of Gastroenterology & Hepatology, 2018, 33(9).

Citations

1. Wang X, Li X, Wang J, et al. SMGL-1/NBAS acts as a RAB-8 GEF to regulate unconventional protein secretion. Journal of Cell Biology. 2022, 221(7): e202111125 2. Zhang T, Wang Y, Li Q, et al. Mesenchymal stromal cells equipped by IFNα empower T cells with potent anti-tumor immunity. Oncogene. 2022: 1-16.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Kinase Inhibitor Library FDA-Approved Kinase Inhibitor Library Inhibitor Library EMA Approved Drug Library Drug Repurposing Compound Library GPCR Compound Library Anti-Aging Compound Library

Related Products

Related compounds with same targets

Ceranib-2 S1p receptor agonist 1 CYM-5541 MHP CYM50308 Vibozilimod BMS-960 W140 HBr

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Fingolimod 162359-55-9 Cytoskeletal Signaling GPCR/G Protein S1P Receptor PAK LPL Receptor Inhibitor inhibit FTY720 FTY 720 FTY-720A Lysophospholipid Receptor FTY-720 p21 activated kinases inhibitor

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