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Fludrocortisone
Fludrocortisone （Florinef） is a synthetic corticosteroid with moderate glucocorticoid potency and greater mineralocorticoid potency. Fludrocortisone is in research use for the treatment of hypotension.[3]
Catalog No. T1666LCas No. 127-31-1
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Fludrocortisone
Catalog No. T1666LAlias Fludrocortisone acetate, Florinef, Astonin, 9α-fluorohydrocortisone, 9α-fluorocortisol, 9α-Fluorcortisol, 9α-FludrocortisoneCas No. 127-31-1
Fludrocortisone （Florinef） is a synthetic corticosteroid with moderate glucocorticoid potency and greater mineralocorticoid potency. Fludrocortisone is in research use for the treatment of hypotension.[3]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $35 | In Stock | |
| 5 mg | $77 | In Stock | |
| 10 mg | $123 | In Stock | |
| 25 mg | $198 | In Stock | |
| 50 mg | $297 | In Stock | |
| 100 mg | $453 | In Stock | |
| 500 mg | $987 | 4-6 weeks | |
| 1 mL x 10 mM (in DMSO) | $111 | In Stock |
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Bioactivity
Chemical Properties
| Description | Fludrocortisone （Florinef） is a synthetic corticosteroid with moderate glucocorticoid potency and greater mineralocorticoid potency. Fludrocortisone is in research use for the treatment of hypotension.[3] |
| In vitro | METHODS: MIO-M1 cells were selected to study the anti-inflammatory effects of Fludrocortisone （Florinef） under IL-1β or TNF-α stimulation. Fludrocortisone was added to the culture medium at a concentration of 1 μg/μl, and 1 ng/μl of IL-1β or TNF-α was added at the same time. RESULTS Fludrocortisone reduced the expression of CCL2, IL-6, and IL-8 to baseline levels after TNF-α stimulation. [2] |
| In vivo | METHODS: Wistar rats were treated intravenously with Fludrocortisone （Florinef） (5 and 20 μg/kg). The effects of a single dose of fludrocortisone on systolic blood pressure in normal and endotoxemic rats were evaluated until 2 h after treatment injection and in vitro vasoconstriction to phenylephrine in mesenteric artery rings 3 h after treatment. RESULTS Fludrocortisone increased systolic blood pressure (P < 0.001), but more in endotoxemic than in normal animals. Fludrocortisone significantly improved the contractile response to phenylephrine (P = 0.039 and P = 0.007, respectively). [1] |
| Alias | Fludrocortisone acetate, Florinef, Astonin, 9α-fluorohydrocortisone, 9α-fluorocortisol, 9α-Fluorcortisol, 9α-Fludrocortisone |
| Molecular Weight | 380.45 |
| Formula | C21H29FO5 |
| Cas No. | 127-31-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (144.57 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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